Gene interactions and pathways from curated databases and text-mining

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ABCC6 — PARP3

Text-mined interactions from Literome

Kogoshi et al., Oncol Rep 2005 (Leukemia...) : To investigate the possible molecular mechanism of the protective effect, the influence of Jagged1 on Ara-C induced activation of caspase-3 and PARP , and dephosphorylation of NF-kappaB was examined in NB4 cells
Engelbrecht et al., J Mol Cell Cardiol 2005 (MAP Kinase Signaling System...) : EPA ( 20microM ) and ARA ( 20microM ) significantly inhibited caspase-3 activation and PARP-cleavage and reduced the apoptotic index during reperfusion
Ibrado et al., Cancer Res 1996 : In contrast, in HL-60/Bcl-2 and HL-60/ Bcl-xL cells, Ara-C induced p32Yama activation by its cleavage, PARP degradation and apoptosis were significantly inhibited ... These results suggest that the activation of the Yama protease and PARP degradation are involved in Ara-C- , etoposide-, or mitoxantrone induced apoptosis