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ACVR1 — BMP2

Pathways - manually collected, often from reviews:

• KEGG Cytokine-cytokine receptor interaction: BMP2 → Complex of ACVR1-BMPR2 (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: ACVR1 — BMP2 (in vivo) ten Dijke et al., J Biol Chem 1994
• IRef Ophid Interaction: ACVR1 — BMP2 (aggregation, confirmational text mining) ten Dijke et al., J Biol Chem 1994
• IRef Ophid Interaction: ACVR1 — BMP2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

de Sousa Lopes et al., Genes Dev 2004 : BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo
Kano et al., Endocrinology 2005 : Furthermore, intracellular BMP signaling was markedly suppressed by dexamethasone treatment and the expression of ALK-2 , ALK-3, and BMPRII was significantly inhibited by dexamethasone
Fukuda et al., J Biol Chem 2009 (Myositis Ossificans) : Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva
Shen et al., J Clin Invest 2009 (Myositis Ossificans) : Through a series of in vitro assays using several mammalian cell lines and chick limb bud micromass cultures, we determined that mutant R206H ACVR1 activated BMP signaling in the absence of BMP ligand and mediated BMP independent chondrogenesis that was enhanced by BMP
Song et al., J Biol Chem 2010 (Myositis Ossificans) : The decreased binding affinity of FKBP1A to the mutant R206H ACVR1 resulted in leaky activation of the BMP signal, and moreover, it decreased steady-state R206H ACVR1 protein levels
Joziasse et al., Eur J Hum Genet 2011 (Down Syndrome...) : These data indicate that in the context of a DS background, ALK2 mediated reduction of BMP signaling may contribute to CHDs
Ohte et al., Biochem Biophys Res Commun 2011 (Myositis Ossificans) : Over-expression of ALK2 ( L196P ) induced BMP-specific activities, including the suppression of myogenesis, the induction of alkaline phosphatase activity, increased BMP-specific luciferase reporter activity, and increased phosphorylation of Smad1/5 but not Erk1/2 or p38
Steinbicker et al., Blood 2011 (Iron Overload) : Both Alk2 and Alk3 were required for induction of hepcidin gene expression by BMP2 in cultured hepatocytes or by iron challenge in vivo
Le et al., Dev Dyn 2012 (Disease Models, Animal...) : Hyperactive BMP signaling induced by ALK2 ( R206H ) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva ... In Drosophila, human ALK2 ( R206H ) receptor induces hyperactive BMP signaling
Choe et al., J Neurosci 2013 : Bmp activation through the Acvr1 receptor induced Lef1 expression and neurogenesis in the embryonic DG