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ACVR1 — BMP4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
de Sousa Lopes et al., Genes Dev 2004
:
BMP signaling
mediated by
ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo
Kano et al., Endocrinology 2005
:
Furthermore, intracellular
BMP signaling was markedly suppressed by dexamethasone treatment and the expression of
ALK-2 , ALK-3, and BMPRII was significantly
inhibited by dexamethasone
Fukuda et al., J Biol Chem 2009
(Myositis Ossificans) :
Constitutively activated
ALK2 and increased SMAD1/5 cooperatively
induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva
Shen et al., J Clin Invest 2009
(Myositis Ossificans) :
Through a series of in vitro assays using several mammalian cell lines and chick limb bud micromass cultures, we determined that mutant R206H
ACVR1 activated
BMP signaling in the absence of BMP ligand and mediated BMP independent chondrogenesis that was enhanced by BMP
Song et al., J Biol Chem 2010
(Myositis Ossificans) :
The decreased binding affinity of FKBP1A to the mutant R206H
ACVR1 resulted in leaky activation of the
BMP signal, and moreover, it decreased steady-state R206H ACVR1 protein levels
Joziasse et al., Eur J Hum Genet 2011
(Down Syndrome...) :
These data indicate that in the context of a DS background,
ALK2 mediated reduction of
BMP signaling may contribute to CHDs
Ohte et al., Biochem Biophys Res Commun 2011
(Myositis Ossificans) :
Over-expression of
ALK2 ( L196P )
induced BMP-specific activities, including the suppression of myogenesis, the induction of alkaline phosphatase activity, increased BMP-specific luciferase reporter activity, and increased phosphorylation of Smad1/5 but not Erk1/2 or p38
Le et al., Dev Dyn 2012
(Disease Models, Animal...) :
Hyperactive
BMP signaling
induced by
ALK2 ( R206H ) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva ... In Drosophila, human
ALK2 ( R206H ) receptor
induces hyperactive
BMP signaling
Matsumoto et al., Steroids 2013
:
The expression of BMPRII was increased by estrogen in MC3T3-E1 cells, and inhibition of BMPRII or
ALK-2/3 signaling
impaired the effect of estrogen on
BMP-4 signaling
Choe et al., J Neurosci 2013
:
Bmp activation through the
Acvr1 receptor induced Lef1 expression and neurogenesis in the embryonic DG