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ADAM17 — MAPK3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhan et al., J Cell Sci 2007
(Mechanotransduction, Cellular) :
TACE release of TNF-alpha mediates mechanotransduction
induced activation of p38
MAPK and myogenesis
Brill et al., Cardiovasc Res 2009
:
TACE activation induced by hydrogen peroxide was
dependent on p38
mitogen activated protein kinase signalling, whereas protein kinase C, phosphoinositide 3-kinase, and caspases were not involved
Yamashita et al., Journal of ovarian research 2009
:
Activation of PKA, p38
MAPK and ERK1/2 by gonadotropins in cumulus cells is
critical for induction of EGF-like factor and
TACE/ADAM17 gene expression during in vitro maturation of porcine COCs ... The results showed that PKA, p38
MAPK and ERK1/2 positively
controlled the expression of EGF-like factor and
TACE/ADMA17 , the latter of which impacts the cumulus expansion and oocyte maturation of porcine COCs via the EGFR-ERK1/2 pathway in cumulus cells
Killock et al., Biochem J 2010
:
The cytoplasmic domains of
TNFalpha converting enzyme ( TACE/ADAM17 ) and L-selectin are
regulated differently by p38
MAPK and PKC to promote ectodomain shedding
Liu et al., J Cell Biochem 2010
(Neuroblastoma) :
Taken together, our data indicate that PLA(2) evoked p38
MAPK activation and ERK inactivation are
involved in
ADAM17 posttranscriptional up-regulation, and suggest that the action of PLA(2) is catalytic activity dependent
Liu et al., J Biol Chem 2010
:
It was found that PILP-1 evoked p38
MAPK activation and ERK inactivation
led to PILP-1 induced cell death and down-regulation of
ADAM17
Van Schaeybroeck et al., Cancer Res 2011
(Colorectal Neoplasms) :
Collectively, our findings indicate that oncogenic Kras regulates
ADAM17 activity and thereby growth factor ligand shedding in a
MEK1/2/Erk1/2 dependent manner and that KrasMT CRC tumors are vulnerable to MEK1/2 inhibitors, at least in part, due to their dependency on ADAM17 activity