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ADCY9 — GAL
Text-mined interactions from Literome
Amiranoff et al., Eur J Biochem 1991
:
The direct inhibitory
effect of
galanin on the
adenylate cyclase activity in Rin14B cell membranes was also demonstrated ( IC50 = 3 nM galanin )
Amiranoff et al., Eur J Biochem 1988
:
Overnight treatment of the Rin m 5F cells with pertussis toxin completely abolished the inhibitory
effect of
galanin on insulin release, cAMP production and
adenylate cyclase activity
Habert-Ortoli et al., Proc Natl Acad Sci U S A 1994
:
The cloned receptor expressed in COS cells specifically binds human, porcine, and rat galanin with high affinity ( Kd in the nanomolar range ) and mediates the
galanin inhibition of
adenylate cyclase
Karelson et al., Neuropeptides 1995
:
Regulation of
adenylate cyclase by
galanin , neuropeptide Y, secretin and vasoactive intestinal polypeptide in rat frontal cortex, hippocampus and hypothalamus ... This study characterizes regional
regulation of
adenylate cyclase by
galanin , neuropeptide Y (NPY), secretin and vasoactive intestinal peptide (VIP) in rat brain frontal cortex, hypothalamus and hippocampus ... In our experimental system,
galanin caused small detectable activation ( 10-20 % ) of basal
adenylate cyclase activity in frontal cortex and hippocampus but had no effect on basal adenylate cyclase activity in hypothalamus