Gene interactions and pathways from curated databases and text-mining

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AKR1C3 — INS

Text-mined interactions from Literome

Du et al., J Clin Endocrinol Metab 2009 : Insulin increased KLF15 mRNA expression according to real-time RT-PCR and increased HSD17B5 promoter activity according to luciferase assays
Dozmorov et al., BMC cancer 2010 (Disease Progression...) : Microarray and bioinformatics analysis suggested that overexpression of AKR1C3 in PC-3 cells modulates estrogen and androgen metabolism, activates insulin-like growth factor (IGF)-1 and Akt signaling pathways, as well as promotes tumor angiogenesis and aggressiveness