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AKT1 — BAX
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Matsuzaki et al., J Neurochem 1999
:
Adenovirus mediated overexpression of the activated form of
Akt significantly
inhibited NO-induced cell death, caspase-3-like activation, and changes in Bcl-2 and
Bax expression
Fahy et al., Br J Cancer 2003
(Adenocarcinoma...) :
Inhibition of either phosphatidylinositol-3 kinase or
AKT led to a decreased protein level of the antiapoptotic gene BCL-2 and an increased protein level of the proapoptotic gene
BAX
Parikh et al., J Immunol 2004
:
Because inhibition of PI3K or its target
Akt also
triggers mitochondrial translocation of
Bax in T cells and apoptosis in Bax transfected cell lines, we generated Bax deletion mutants to identify the region ( s ) that confers sensitivity to regulation by MEK1 and Akt
Shacka et al., Cell Death Differ 2006
:
Furthermore, overexpression of constitutively active
Akt inhibits both peroxynitrite induced
Bax translocation and cell death
Zhang et al., Neuroscience 2006
(Disease Models, Animal...) :
Akt activation results in decreased serine phosphorylation of 14-3-3, a cytoplasmic anchor of Bax, and
prevents ischemia induced mitochondrial translocation of
Bax , release of cytochrome c, and activation of caspase-3
Salah et al., Mol Cancer Res 2007
(Disease Progression...) :
The activation of PAR1 induced
pAkt/protein kinase B abrogated serum deprived Bim ( EL ) induction and also markedly
inhibited Bax levels
Kim et al., Cancer Lett 2008
(Leukemia, Promyelocytic, Acute) :
Overexpression of
Akt also
led to suppression of
Bax translocation to mitochondria during ceramide induced apoptosis in HL-60 cells
Jane et al., Cancer Lett 2008
(Glioma) :
Simultaneous exposure to both agents significantly increased the release of cytochrome c, as well as caspase 3 activation,
Bax cleavage, and
inhibition of
Akt phosphorylation
Festuccia et al., Endocr Relat Cancer 2009
(Disease Models, Animal...) :
In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA,
Bax , Bak, p21/WAF1, and p27/KIP1, and
inhibiting the activation of
Akt activity and the expression of cyclin D1, Bcl-2, and Bcl-XL
Sadidi et al., Biochimie 2009
:
Hydrogen peroxide induced
Akt phosphorylation
regulates Bax activation
Kolliputi et al., Am J Physiol Lung Cell Mol Physiol 2009
(Acute Lung Injury...) :
IL-6 cytoprotection in hyperoxic acute lung injury occurs via
PI3K/Akt mediated
Bax phosphorylation ... Thus IL-6 functions in a cytoprotective manner, in part, by suppressing Bax translocation and dimerization through
PI3K/Akt mediated
Bax phosphorylation
Wang et al., J Am Soc Nephrol 2009
:
Because
Akt regulates
Bax , we examined the effects of the beta-catenin mutants on Akt expression and activation ... Constitutively active beta-catenin increased Akt-1 expression and activation before and after stress, and treatment with a phosphatidylinositol-3 kinase inhibitor antagonized the protective effects of beta-catenin on
Akt activation,
Bax inhibition , and cell survival ... Taken together, these results suggest that beta-catenin/Wnt signaling promotes survival of renal epithelial cells after metabolic stress, in part by inhibiting
Bax in a phosphatidylinositol-3
kinase/Akt dependent manner
Ye et al., Cardiovasc Drugs Ther 2010
(Myocardial Infarction...) :
Both PIO and TAK-491 increased
Akt , ERK 1/2 and eNOS phosphorylation and
inhibited BAX activation
Premkumar et al., Int J Oncol 2010
(Glioblastoma) :
Overexpression of Bcl-2 and
Akt significantly attenuated NVP-AEW541 and dasatinib
induced Bax activation and cell death
Mou et al., Toxicol In Vitro 2011
(Carcinoma, Non-Small-Cell Lung) :
Furthermore, celastrol induced the release of cytochrome c. Celastrol also up-regulated the expression of pro-apoptotic
Bax , down-regulated anti-apoptotic Bcl-2, and
inhibited Akt phosphorylation
Zhang et al., Int J Radiat Oncol Biol Phys 2012
(Lung Injury...) :
Apoptosis correlated with increased PTEN expression,
inhibition of downstream
PI3K/AKT signaling, and increased p53 and
Bax protein levels
Zhou et al., Kidney Int 2012
(Acute Kidney Injury...) :
In vitro activation of ß-catenin by Wnt1 or stabilization of ß-catenin protected tubular epithelial cells from apoptosis, activated
Akt , induced survivin, and
repressed p53 and
Bax expression
Guo et al., Zhonghua Xue Ye Xue Za Zhi 2012
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
Oridonin inhibited activation of ABL kinase and its downstream
Akt/mTOR , Raf/MEK/ERK and STAT5 signaling pathways, which were constitutively activated in SUP-B15 cell line, down-regulated the level of anti- apoptotic protein Bcl-2 and
up-regulated the expression of pro-apoptotic protein
Bax
Lin et al., Zhonghua Xue Ye Xue Za Zhi 2013
:
The expression of Mcl-1, Bcl-xl, Bid and Bim protein decreased gradually, but the expression of
Bax , Bak and Bad protein
increased , and the expression of
p-AKT protein ( 60 kDa ) and NF-?B obviously decreased