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AKT1 — CPOX
Text-mined interactions from Literome
Lee et al., J Biol Chem 2003
:
LY294002, dominant negative ( DN ) phosphatidylinositol 3-kinase (PI3K), or
AKT ( DN )
inhibited NFkappaB activation, p65 transactivation, and
cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active ( CA ) TLR4
Chang et al., Mol Pharmacol 2004
:
The YC-1 induced increase in
COX activity was also
blocked by manumycin A, wortmannin, PDTC, and the dominant negative mutants for Ras ( RasN17 ),
Akt ( Akt DN ), and IkappaBalpha ( IkappaBalphaM )
Ning et al., Radiat Res 2007
:
Both radiation and cRGD induced
Akt phosphorylation,
up-regulated COX2 expression, and increased PGE2 production in HUVECs
Hill et al., Mol Cancer Ther 2012
(Carcinoma, Pancreatic Ductal...) :
Mechanistically,
COX-2 overexpression
increases p-AKT levels in the precursor lesions of Pdx1 ( + ) ; K-ras ( G12D ) ( /+ ) ; Pten ( lox ) ( /+ ) mice in the absence of Pten LOH
GutiƩrrez-Venegas et al., Mol Biol Rep 2013
(Chronic Periodontitis) :
We studied the role of the flavonoids fisetin, luteolin, myricetin, and morin in inhibiting the activation of mitogen activated protein kinase ( MAPK ) and
AKT as well as their
role in lipopolysaccharide (LPS) induced
cyclooxygenase-2 (COX-2) transcription