Gene interactions and pathways from curated databases and text-mining

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AKT1 — CXCL2

Text-mined interactions from Literome

Sai et al., J Biol Chem 2006 : Although both mutant and wild-type receptors could mediate Akt and Erk activation in response to CXCL8 , the level of activation of these two kinases was much lower in the cell line expressing the mutant receptors
Brkovic et al., J Leukoc Biol 2007 : Finally, both angiopoietins showed a synergistic effect on the induction of Akt phosphorylation mediated by CXCL8/IL-8
Petrai et al., Int J Biochem Cell Biol 2008 : In cells expressing CXCR3-A, CXCL10 ( IP-10 ) at nanomolar concentrations induced activation of ERK, Akt , and Src, as previously described in human vascular pericytes
Korniejewska et al., Immunology 2011 : We report that CXCL4 induces intracellular calcium mobilization as well as Akt and p44/p42 extracellular signal regulated kinase phosphorylation, in activated human T lymphocytes
Lin et al., J Biol Chem 2011 : In this study, we further investigated the roles of Rac1, phosphoinositide 3-kinase (PI3K), and Akt in thrombin induced NF-?B activation and IL-8/CXCL8 expression
Sahin et al., Hepatology 2013 (Carbon Tetrachloride Poisoning...) : Specifically, CXCL10 induced long-term protein kinase B and Jun N-terminal kinase activation, leading to hepatocyte apoptosis by caspase-8, caspase-3, and p21 activated kinase 2 cleavage