Gene interactions and pathways from curated databases and text-mining

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AKT1 — TCF4

Text-mined interactions from Literome

Brunet et al., Mol Cell Biol 2001 : These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites
Hutchinson et al., Mol Cell Biol 2001 (Hyperplasia...) : Furthermore, coexpression of Akt-DD with MTY315/322F resulted in phosphorylation of the FKHR forkhead transcription factor and translational upregulation of cyclin D1 levels
Patel et al., J Biol Chem 2002 : The signaling pathway that mediates these events requires the activation of phosphatidylinositol 3-kinase, whereas transfection studies have suggested an involvement of Akt ( protein kinase B ) and FKHR, a transcription factor regulated by Akt
van den Heuvel et al., J Cell Sci 2002 : This also resulted in inhibition of nuclear PKB signalling as indicated by inhibition of PKB dependent Forkhead transcription factor regulation
Wrede et al., J Biol Chem 2002 (Necrosis) : Further analysis of pro-apoptotic downstream targets of PKB, implicated a role for PKB mediated phosphorylation inhibition of glycogen synthase kinase-3alpha/beta and the forkhead transcription factor , FoxO1, in protection of FFA induced beta-cell apoptosis
Vojtek et al., Mol Cell Biol 2003 : Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation
Christian et al., J Biol Chem 2003 : Preventing Rap activation also increased the ability of the BCR to stimulate Akt dependent phosphorylation of the FKHR transcription factor on negative regulatory sites and decreased the levels of p27Kip1, a pro-apoptotic factor whose transcription is enhanced by FKHR
Figueroa et al., Oncogene 2003 : Here, we show that Akt regulates the Elk-1 transcription factor , independent of its negative regulation of Raf kinases
Lee et al., Mol Cancer Res 2004 (Breast Neoplasms...) : Stromal cell derived factor 1alpha ( SDF-1alpha ; CXCL12 ) stimulation of breast cancer cells resulted in phosphoinositide 3-kinase (PI-3K) activation, AKT phosphorylation, and activation of the FKHRL1 transcription factor
Orth et al., Regul Pept 2004 : The transcription factor FKHR ( FOXO1a ) is regulated by protein kinase B (PKB) and insulin controls the expression of hepatic genes like glucose-6-phosphatase (G6Pase) at least in part via these proteins
Smith et al., J Biol Chem 2005 : Furthermore, DEX mediated inhibition of LEF/TCF transcriptional activity was attenuated in the presence of dominant negative forms of either PI3K or protein kinase B/Akt ... Furthermore, DEX mediated inhibition of LEF/TCF transcriptional activity was attenuated in the presence of dominant negative forms of either PI3K or protein kinase B/Akt
Stayrook et al., Endocrinology 2005 (Carcinoma, Hepatocellular) : Activation of FXR initiated a cascade involving induction of peroxisome proliferator activated receptor alpha and TRB3 expression that is consistent with stimulation of PEPCK gene expression via interference with a pathway that may involve Akt dependent phosphorylation of Forkhead/winged helix transcription factor ( FOXO1 )
Fabre et al., J Immunol 2005 : This persistent activation of PI3K results in the Akt dependent sequestration of the FoxO transcription factor , FoxO1, outside the nucleus of T cells interacting with APCs
Dihlmann et al., Carcinogenesis 2005 (Colonic Neoplasms...) : Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells
Jung et al., Mol Endocrinol 2005 (Carcinoma, Papillary...) : The activation of PKB by RET/PTC blocked the activity of the forkhead transcription factor , FKHRL1, but a Y315F mutant of PKB failed to inhibit FKHRL1 activity
Maclachlan et al., Int J Radiat Biol 2005 (Radiation Injuries) : In vitro exposure to FGF-20 increased expression of the Nrf2 transcription factor and oxygen radical scavenging enzymes such as MnSOD, activated signal transduction pathways ( ERK and Akt ) and resulted in increased survival of irradiated cells in vitro
Belaiba et al., Mol Biol Cell 2007 (Anoxia) : Furthermore, inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT but not extracellular signal regulated kinase 1/2 pathway blocked the hypoxia dependent induction of HIF-1alpha mRNA and HIF-1alpha promoter activity, suggesting involvement of a PI3K/AKT regulated transcription factor
Seiliez et al., J Nutr 2008 : In mammals, the ubiquitin-proteasome proteolytic pathway is a major route of protein degradation and has been shown to be regulated by the feeding status via the protein kinase B (PKB)-Forkehead box-O transcription factor signaling pathway mediated transcription regulation of atrophy related ubiquitin ligases, atrogin1 and muscle RING finger 1
Kong et al., Neurol Res 2009 (Huntington Disease) : The level of active Akt was significantly elevated in STHdh ( Q111 ) compared to STHdh ( Q7 ) resulting in the phosphorylation of a FKHRL1, a forkhead transcription factor regulating Bim expression in neuronal cells
Michalek et al., Mol Cell 2008 : In this issue of Molecular Cell, Yamagata et al. ( 2008 ) identify a role for the protein methyltransferase, PRMT1, in Akt dependent regulation of the FOXO1 transcription factor and demonstrate another level of control in this critical metabolic and cell survival signaling pathway
Urano-Tashiro et al., J Neurosci Res 2010 : Implication of Akt dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation ... Here, we demonstrated that PRP19 alpha/14-3-3beta/CDC5L complex formation is regulated by Akt during nerve growth factor (NGF) induced neuronal differentiation of PC12 cells
Zhang et al., Circ Res 2010 (Diabetes Mellitus) : Moreover, inhibition of Akt signaling attenuated the phosphorylation of forkhead box O transcription factor ( FOXO)-3a and enhanced atrogin-1 expression, which in turn suppressed BK-ß ( 1 ) protein levels in human CASMCs