Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Huang et al., Cardiovasc Drugs Ther 2011 (Disease Models, Animal...) : LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor ( Rp-cAMPS ) or Akt-inhibitor ( AKT 1/2 kinase inhibitor )
Peng et al., Genes Dev 2003 (Abnormalities, Multiple...) : Specifically, Akt1 and Akt2 are required for the induced expression of PPARgamma, the master regulator of adipogenesis, establishing a new essential role for Akt in adipocyte differentiation