Taylor et al., Oncogene 2002
(Breast Neoplasms) :
The generation of MMP2 is mediated by activation of phospholipase A ( 2 ) and 5-lipoxygenase Seo et al., Atherosclerosis 2010
:
Thus, this study investigated the role of 5-LO in HNE enhanced MMP-2 production in VSMC, and the mechanisms by which this enzyme could be activated by HNE ... Collectively, these data suggest that 5-LO mediates HNE enhanced MMP-2 production via LTB ( 4 ) -BLT receptor pathways, consequently leading to atherosclerotic plaque instability