Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — FOXO1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: ANGPT2 → FOXO1 (directlyDecreases, ANGPT2 Activity) Potente et al., J Clin Invest 2005*
    Evidence: Whereas angiopoietin 2 (Ang2) was exclusively regulated by Foxo1, eNOS, which is essential for postnatal neovascularization, was regulated by Foxo1 and Foxo3a. Consistent with these findings, constitutively active Foxo1 and Foxo3a repressed eNOS protein expression and bound to the eNOS promoter.

Text-mined interactions from Literome

Potente et al., J Clin Invest 2005 (Ischemia) : Whereas angiopoietin 2 (Ang2) was exclusively regulated by Foxo1 , eNOS, which is essential for postnatal neovascularization, was regulated by Foxo1 and Foxo3a
Daly et al., Proc Natl Acad Sci U S A 2006 : Here, we demonstrate that Ang-2 expression is rapidly induced in endothelial cells by the transcription factor FOXO1 after inhibition of the phosphatidylinositol 3-kinase/Akt pathway ... In addition, we show that Ang-2 , like Ang-1, activates Tie2/Akt signaling in vivo, thereby inhibiting the expression of FOXO1 target genes
Goettsch et al., J Cell Physiol 2008 : Our results support a VEGF dependent induction of Ang-2 in low flow areas, and FOXO1 dependent downregulation of Ang-2 in high flow areas
Dixit et al., Cardiovasc Res 2008 : As FoxO1a regulates the expression of angiopoietin-2 (Ang-2) , we determined the role of shear stress and the AMPK in this phenomenon ... Moreover, as the AMPK dependent phosphorylation and degradation of FoxO1a attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha, this kinase may be a useful target to prevent the progression of vascular diseases