Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Pareek et al., Proc Natl Acad Sci U S A 2006 (Inflammation...) : Increased calpain activity in sensory neurons after inflammation resulted in the cleavage of p35 to p25, which forms a more stable complex with Cdk5 and, consequently, leads to elevation of Cdk5 activity
Kamei et al., J Biol Chem 2007 (Neurodegenerative Diseases) : Suppression of calpain dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation
Seyb et al., J Mol Neurosci 2007 : Recent evidence supports A beta induction of a calpain dependent cleavage of the cyclin dependent kinase 5 (cdk5) regulatory protein p35 that contributes to tau hyperphosphorylation and neuronal death
Chen et al., Brain Res 2008 (Alzheimer Disease...) : The cleavage of p35 to p25, mediated by calpain and calcium, caused CDK5 dislocation and subsequently p25/CDK5 induced tau hyperphosphorylation, which disrupted the cytoskeleton and resulted in neuronal death