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AKT3 — ARSK
Text-mined interactions from Literome
Wu et al., Neurosci Lett 2006
(Brain Ischemia) :
Down-regulation of PTEN by sodium orthovanadate inhibits
ASK1 activation via
PI3-K/Akt during cerebral ischemia in rat hippocampus
Taniike et al., Circulation 2008
(Cardiomegaly...) :
Furthermore, the inhibition of
ASK1 or p38 activity enhanced insulin-like growth factor 1-induced protein synthesis in rat neonatal ventricular cardiomyocytes, and the treatment with a specific inhibitor of p38
resulted in enhancement of
Akt activation and suppression of protein phosphatase 2A activation
Xu et al., Neuropharmacology 2008
(Brain Ischemia...) :
In particular, our study showed that co-activation of GABA A and GABA B receptors could strongly increase
Akt activation and
inhibit ASK1 activation by phosphorylation of serine 83 of ASK1
Xie et al., Proc Natl Acad Sci U S A 2009
(Prostatic Neoplasms) :
Gain of function study showed that DAB2IP can suppress the PI3K-Akt pathway and
enhance ASK1 activation leading to cell apoptosis, whereas loss of DAB2IP expression resulted in
PI3K-Akt activation and ASK1-JNK inactivation leading to accelerated PCa growth in vivo
Pan et al., Chem Res Toxicol 2010
:
Silencing
Akt by siRNA
reduced the activation of
ASK1 and p38 MAPK and cell apoptosis, whereas without nickel stimulation, siRNA Akt had no effect on the activation of ASK1 and p38 MAPK