Gene interactions and pathways from curated databases and text-mining

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B2M — IFNG

Text-mined interactions from Literome

Lee et al., Cancer Res 2000 (Neoplasm Metastasis...) : IFN-gamma induced surface class I MHC expression, as well as gene expression of TAP-1, TAP-2, LMP-2, and LMP-7 in the metastatic cells, yet the cells remained resistant to cell lysis induced by CTLs. Interestingly, although in comparison to the primary cells the metastatic cells were resistant to cytolysis, both cell types were susceptible to DNA fragmentation induced by CTLs. Cell fusion between primary and metastatic cancer cells resulted in hybrids that also resisted the cytolytic activity of CTLs
Hurks et al., Invest Ophthalmol Vis Sci 2001 (Melanoma...) : Notably, all cell lines expressed HLA-E , and this expression was significantly enhanced by interferon-gamma
Turnley et al., J Neuroimmunol 2002 : Neurons from SOCS1 null mice expressed class I MHC in response to IFNgamma , while SOCS1 overexpression in glia inhibited MHC induction
Coccia et al., J Biol Regul Homeost Agents 1992 (Leukemia, Erythroblastic, Acute) : Transcriptional induction of H2 ( class I ) antigens and beta 2 microglobulin by interferon-gamma in interferon-sensitive and interferon-resistant Friend leukemia cells
Chong et al., J Immunol 2004 (Diabetes Mellitus, Type 1...) : Additionally, IFN-gamma induced class I MHC up-regulation and TNF- and IFN-gamma induced IL-15 expression by beta cells were inhibited by SOCS-1, which correlated with suppressed 8.3 T cell proliferation in vitro
Sibille et al., Eur J Immunol 1992 : Our data suggests that IFN-gamma reestablishes class I MHC surface expression by restoring access of endogenously synthesized peptide to class I molecules
Salerno-Gonçalves et al., J Immunol 2004 : These results demonstrate that HLA-E binds nonamer peptides derived from bacterial proteins and trigger CD8+ mediated lysis and IFN-gamma production when exposed to infected targets, raising the possibility that this novel effector mechanism might contribute to host defense against intracellular bacterial infections
Mitsdoerffer et al., J Neuroimmunol 2005 (Multiple Sclerosis, Relapsing-Remitting) : Although both IFN-beta and IFN-gamma strongly enhance HLA-G1 and HLA-G5 expression by monocytes in vitro, IFN-beta leads to a stronger relative upregulation of HLA-G compared to classical MHC class I molecules than stimulation with IFN-gamma
Bono et al., Res Immunol 1991 : It has previously been shown that stimulation of class I MHC antigen expression by human interferon gamma ( Hu-IFN gamma ) depends on the presence of both human chromosomes 6 and 21 ... Only the hybrid containing the human chromosome 21 ( GM08-gamma R.9 ) exhibited a biological response when assayed for the stimulation of murine class I MHC antigen expression by Hu-IFN gamma
Derré et al., J Immunol 2006 (Disease Susceptibility...) : IFN-gamma significantly increased the surface expression of HLA-E and the shedding of soluble HLA-E by these cells, in a metalloproteinase dependent fashion
Hakem et al., J Immunol 1991 : The transcription of HLA-A3 and HLA-B7 class I genes is differentially regulated by IFN-alpha and -gamma , the latter gene being more inducible than the former
Moyer et al., Exp Cell Res 1992 (Autoimmune Diseases...) : The cells do not express Class I MHC antigens ; however, IFN-beta and IFN-gamma stimulate Class I MHC expression after 24 h, which induces lysis of virus infected cloned endothelium by Class I-restricted virus primed T cells
Levy et al., Int J Oncol 2008 (Carcinoma...) : Moreover, we analysed HLA-E expression in several colorectal cancer cell lines and demonstrated that IFN-gamma upregulates the expression of membrane HLA-E in vitro
Nguyen et al., Bone Marrow Transplant 2009 (Leukemia, Myeloid, Acute) : We show that IFN-gamma produced by immature CD56 ( bright ) NK cells upregulates cell surface expression of HLA-E on AML blasts and that this upregulation protects leukemic cells from NK-mediated cell lysis through the mediation of CD94/NKG2A, an inhibitory receptor overexpressed on NK cells after haploidentical SCT
Rich et al., J Interferon Res 1990 : These results are discussed with regard to the further study of AKR SL3 to better understand IFN-gamma regulation of class I MHC expression
Chen et al., Mol Cell Biol 1986 (Leukemia, Myeloid, Acute) : In the uninduced state, K562 cells show little or no class I gene expression but actively express the erythroid-specific gamma-globin gene as well as genes associated with cell proliferation, including the transferrin receptor, c-myc, and alpha-actin genes At both the surface protein and mRNA levels, IFN-gamma induces class I and beta 2-microglobulin gene expression, but does not alter the expression of the gamma-globin, transferrin receptor, c-myc, or alpha-actin genes
Niederwieser et al., J Immunol 1988 : IFN-gamma induces, as expected, a strong increase in class I MHC Ag expression as well as de novo expression of class II MHC Ag, whereas IFN-alpha 2 only slightly increases class I MHC Ag and does not induce keratinocytes to express class II MHC Ag
Takemura et al., Exp Hematol 1989 (Leukemia, Myeloid) : These results indicate that class I MHC antigen expression on K562 cells can be induced by IFN-gamma in cooperation with TNF in a manner different from myeloid antigen expression
Campbell et al., Diabetes 1986 (Adenoma, Islet Cell...) : Expression of class I MHC proteins on RIN-m5F cells is increased by interferon-gamma and lymphokine conditioned medium
Andrews et al., Cancer Res 1987 (Cell Transformation, Viral...) : However, developmental regulation of responsiveness to IFN was evident, since IFN-gamma induced higher levels of surface expression of HLA-A, B, C and beta 2-microglobulin in the retinoic acid induced differentiated NTERA-2 cl.D1 cells than in the undifferentiated parental cells
Hunt et al., J Immunol 1986 : Interferon-gamma induces class I HLA and beta 2-microglobulin expression by human amnion cells
Green et al., J Immunol 1986 (Leukemia, Experimental) : The results presented here indicate that recombinant murine interferon-gamma can cause a dramatic differential induction of two distinct class I MHC molecules
Wedgwood et al., Cell Immunol 1988 : Similarly, IFN-gamma increases the expression of class I MHC molecules two- to fivefold
Carrel et al., Eur J Immunol 1985 (Colonic Neoplasms...) : IFN-gamma also enhanced the expression of HLA-ABC and beta 2-microglobulin , as well as HLA-DR on DR+ melanoma cells
Basham et al., J Immunol 1983 (Melanoma) : We report here that recombinant interferon-gamma (IFN-gamma) increases the synthesis and expression of the HLA-DR ( la-like ) antigens as well as beta 2-microglobulin ( beta 2-m ) , a low m.w. subunit of HLA, on human melanoma cells
Satoh et al., Neurology 1995 : Furthermore, IFN-beta significantly reduced IFN-gamma induced expression of class II MHC antigen but not of class I MHC antigen or of ICAM-1
Ritter et al., Immunology 1994 : In spite of the minimal effect of IFN-gamma and no effect of IFN-alpha on class I MHC expression, pretreatment of target cells with both cytokines considerably increased their lytic susceptibility
Keskinen et al., Immunology 1997 (Influenza, Human) : Stimulation of peripheral blood mononuclear cells ( PBMC ) with IFN-alpha and IFN-gamma resulted in a 1.5- to twofold increase in HLA class I and beta 2-microglobulin expression in lymphocytes and monocytes
Dias et al., Int J Cancer 1998 (Mammary Neoplasms, Experimental) : IFN-gamma induced beta 2-microglobulin and IDO over a 7-day period, but IP-10 was induced only transiently
Thomas et al., J Clin Invest 1998 (Diabetes Mellitus, Type 1) : IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes ... This study dissociates class I MHC upregulation from progression to diabetes, shows that the rise in class I MHC is due to local IFN-gamma action, and eliminates beta cells as the targets of IFN-gamma in autoimmune diabetes