Gene interactions and pathways from curated databases and text-mining

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BCL2 — TLR2

Text-mined interactions from Literome

Shi et al., J Biol Chem 2008 : TLR signaling enhances the interaction of MyD88 and Trif with Beclin 1, and reduces the binding of Beclin 1 to Bcl-2 ... These findings indicate TLR signaling via its adaptor proteins reduces the binding of Beclin 1 to Bcl-2 by recruiting Beclin 1 into the TLR signaling complex leading to autophagy
Chaturvedi et al., J Biol Chem 2010 (Tuberculosis) : Taken together, our investigation identified PE_PGRS11 as an in vivo expressed immunodominant antigen that plays a crucial role in modulating cellular life span restrictions imposed during oxidative stress by triggering TLR2 dependent expression of COX-2 and Bcl2