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BDNF — VEGFA

Text-mined interactions from Literome

Takeda et al., Tissue Eng 2005 : BDNF stimulated mRNA expression of vascular endothelial growth factor-B and tenascin-X, and proliferation and angiogenesis in human endothelial cells
Nakamura et al., Cancer Res 2006 (MAP Kinase Signaling System...) : Brain derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells ... Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expression ... VEGF mRNA levels in neuroblastoma cells cultured in serum-free media increased after 8 to 16 hours in BDNF ... BDNF induced increases in VEGF and HIF-1alpha protein, whereas HIF-1beta levels were unaffected ... BDNF induced a 2- to 4-fold increase in VEGF promoter activity, which could be abrogated if the hypoxia response element in the VEGF promoter was mutated ... Transfection of HIF-1alpha small interfering RNA blocked BDNF stimulated increases in VEGF promoter activity and VEGF protein expression ... The BDNF stimulated increases in HIF-1alpha and VEGF expression required TrkB tyrosine kinase activity and were completely blocked by inhibitors of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways
Sun et al., Tumour Biol 2010 (Multiple Myeloma) : Brain derived neurotrophic factor induces proliferation, migration, and VEGF secretion in human multiple myeloma cells via activation of MEK-ERK and PI3K/AKT signaling ... Stimulation by BDNF of vascular endothelial growth factor ( VEGF ) production was analyzed by reverse transcriptase-polymerase chain reaction and enzyme linked immunosorbent assay ... VEGF is induced by BDNF in a dose dependent manner in MM cells
Nakamura et al., Mol Cell Neurosci 2011 : We evaluated the molecular mechanisms by which Nerve Growth Factor (NGF) and Brain derived neurotrophic factor (BDNF) regulate VEGF production ... In CGN neurons, BDNF induces VEGF that is dependent on induction of HIF-1a
Li et al., Zhongguo Dang Dai Er Ke Za Zhi 2011 (Neuroblastoma) : The synthesis and secretion of VEGF can be inhibited by blocking TrkB-BDNF signal pathway with K252a or blocking the TrkB-BDNF downstream signal pathway PI3K/Akt with LY294002