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AKT3 — BMI1

Text-mined interactions from Literome

Fan et al., Molecular cancer 2009 (Prostatic Neoplasms) : Conversely, BMI1 reduces PTEN 's ability to inhibit AKT activation, which can be attributed to its interaction with PTEN in the nucleus, making PTEN unavailable to dephosphorylate membrane bound PIP3
Zhang et al., Molecular cancer 2010 (Cell Transformation, Neoplastic...) : Downregulation of BMI1 by Mel-18 overexpression or knockdown of BMI1 expression in gastric cancer cell lines led to upregulation of p16 ( p16INK4a or CDKN2A ) in p16 positive cell lines and reduction of phospho-AKT in both p16 positive and p16 negative cell lines
Kim et al., PloS one 2011 : p38 MAPK Mediated Bmi-1 down-regulation and defective proliferation in ATM-deficient neural stem cells can be restored by Akt activation
Hyland et al., J Virol 2011 : We further show for the first time that transformation with the HPV16 E6 and E7 oncogenes also results in an increase in phosphorylated EZH2 serine 21 ( P-EZH2-Ser21 ), mediated by active Akt , and in a downregulation of the PRC1 protein BMI1 in these cells
Nacerddine et al., J Clin Invest 2012 (Adenocarcinoma...) : Akt mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer
Liu et al., Science signaling 2012 : Moreover, Akt mediated phosphorylation of Bmi1 also inhibited its ability to promote self-renewal of hematopoietic stem and progenitor cells
Chou et al., Cancer Res 2013 (Chromosomal Instability...) : First, BMI1 activated the Akt pathway, thereby upregulating AURKA expression through activation of the ß-catenin/TCF4 transcription factor complex