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CAPN5 — NOS3

Text-mined interactions from Literome

Su et al., Am J Physiol Lung Cell Mol Physiol 2000 (Anoxia) : Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells
Stalker et al., FASEB J 2003 : Immunoprecipitation studies revealed that glucose induces loss of NO via a calpain dependent decrease in the association of hsp90 with endothelial nitric oxide synthase
Stalker et al., Diabetes 2005 (Diabetes Mellitus, Type 2) : Immunoprecipitation studies revealed calpain dependent loss of association between eNOS and the regulatory protein heat shock protein 90
Cui et al., Am J Respir Cell Mol Biol 2005 : Involvement of calpain-calpastatin in cigarette smoke induced inhibition of lung endothelial nitric oxide synthase ... In this study, we evaluated the role of calpain-calpastatin in CSE induced decrease in eNOS gene expression ... To investigate whether CSE induced inhibition of eNOS gene expression is caused by decreased calpain activity due to an increase in calpastatin protein content, we cloned calpastatin gene from PAEC and constructed adenovirus vectors containing calpastatin ... These results indicate that CSE induced inhibition of eNOS expression in PAEC is caused by calpain inhibition due to an increase in calpastatin protein content
Dong et al., J Cell Mol Med 2009 : Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase ... HOG-LDL may impair endothelial function by inducing calpain mediated eNOS degradation in a ROS- and Ca ( 2+ ) -dependent manner
Averna et al., J Biol Chem 2008 : We propose that the protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase
Prangsaengtong et al., Hum Cell 2012 : Calpain 1 is involved in the degradation of eNOS and Hsp90 and the phosphorylation of eNOS, while calpain 2 regulates eNOS phosphorylation during cord formation by lymphatic endothelial cells on Matrigel
Brorson et al., Stroke 1995 : Among various processes that have been thought to mediate the toxic effects of glutamate are activation of the Ca ( 2+ ) -dependent proteases calpain I and II and the activation of nitric oxide synthase