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CASP3 — NFKBIA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Reuther et al., J Biol Chem 1999
:
The involvement of NF-kappaB in the inhibition of cell death led us to ask whether apoptotic stimuli would induce the
caspase mediated cleavage of
IkappaBalpha in vivo ... Since activated NF-kappaB plays a role in the inhibition of cell death, these data suggest that
caspase mediated cleavage of
IkappaBalpha may be a mechanism to suppress NF-kappaB and its associated antiapoptotic activity
Kim et al., J Cell Biochem 2002
:
During apoptosis of NIH3T3, Jurkat, Rat-1, and L929 cells exposed to tumor necrosis factor (TNF) related apoptosis inducing ligand ( TRAIL ), Fas, serum deprivation, or TNF-alpha, respectively,
IkappaBalpha was cleaved in a
caspase dependent manner
Baxa et al., Biochem Pharmacol 2003
(Lymphoma, T-Cell) :
Genistein reduces NF-kappa B in T lymphoma cells via a
caspase mediated cleavage of
I kappa B alpha
Schölzke et al., Eur J Neurosci 2003
:
Specific inhibitors of the proteasome,
caspase 3, and the phosphoinositide 3-kinase
had no effect on glutamate induced
IkappaBalpha degradation
Rathore et al., J Biol Chem 2004
:
The late phase of TRAIL induced NF-kappaB activation involves
caspase mediated cleavage of
IkappaBalpha between Asp ( 31 ) and Ser ( 32 ) residues to generate an N-terminal truncated fragment that is degraded by the proteasome via the N-end rule pathway
Jin et al., Cancer Res 2005
(Prostatic Neoplasms) :
Overexpression of an
IkappaBalpha dominant negative mutant
blocked not only CD437 induced p65 nuclear translocation but also DR4 up-regulation,
caspase activation, and DNA fragmentation
Calvaruso et al., Mol Cell Biochem 2006
(Liver Neoplasms) :
Bortezomib induces in HepG2 cells
IkappaBalpha degradation
mediated by
caspase-8 ... These findings suggest that
caspase-8 can be
involved in the control of
IkappaBalpha level
Pyo et al., J Neurosci Res 2010
(Neuroblastoma) :
Our results suggest that glutamate excitotoxicity in motor neurons of SOD1 linked fALS is attributable, at least in part, to the impairment of
IkappaBalpha dependent RelA activation and subsequent apoptosis mediated by XIAP inhibition and
caspase-3 activation