Gene interactions and pathways from curated databases and text-mining

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CASP3 — STX1A

Text-mined interactions from Literome

Kojio et al., FEMS Immunol Med Microbiol 2000 : The findings suggest that Stx1 as well as Stx2 activate caspase-3 , which plays a critical role in apoptosis, and that the apoptotic signals rise after Stx is transported to the Golgi apparatus
Kiyokawa et al., J Cell Biochem 2001 (Burkitt Lymphoma) : Although the precise mechanism of Stx1 mediated activation of caspase-8 is still unclear, we have demonstrated that crosslinkage of CD77, a functional receptor for Stx1, with specific antibody is sufficient to induce activation of caspase-8
Ching et al., Infect Immun 2002 : Cleavage of caspase-9 and the proapoptotic member of the Bcl-2 family BID was also induced by Stx1 , as determined by immunoblot analyses
Talukder et al., Microb Pathog 2012 : Inhibition of caspase-3 reduced STX-1 induced phosphorylation of H2AX and nuclear condensation