Gene interactions and pathways from curated databases and text-mining

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CASP5 — PIN1

Text-mined interactions from Literome

Atabay et al., J Neurochem 2012 (Neurodegenerative Diseases) : Here, we show that inhibition of Pin1 by its selective inhibitor juglone leads to up-regulation of cyclinD1, phospho-tau, and caspase 3, producing apoptosis in cultured rat hippocampal neurons
Ghosh et al., J Biol Chem 2013 (Parkinson Disease...) : Interestingly, multiple pharmacological Pin1 inhibitors, including juglone, attenuated MPP ( + ) -induced Pin1 up-regulation, a-synuclein aggregation, caspase-3 activation, and cell death