Gene interactions and pathways from curated databases and text-mining

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CASP8 — PLK1

Text-mined interactions from Literome

Rödel et al., Am J Pathol 2010 (Rectal Neoplasms) : A significant decrease of PLK1 expression by siRNAs in combination with ionizing radiation induced an increased percentage of apoptotic cells and increased caspase 3/7 activity
Peterson et al., Cancer Res 2010 (Adenocarcinoma...) : To identify genes whose expression influences the rate and extent of apoptosis after mitotic arrest, we screened a kinase enriched small interfering RNA library for effects on caspase activation in response to maximally effective doses of paclitaxel, a PLK1 inhibitor, or cisplatin