Gene interactions and pathways from curated databases and text-mining

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CASP9 — E2F3

Text-mined interactions from Literome

Afshar et al., Cancer Res 2006 (Glioma) : In a system of inducible E2F1 activity, E2F1 activated caspase-8 and, accordingly, decreased cellular viability, effects that were abolished by caspase-8 siRNA
Wu et al., Acta Pharmacol Sin 2011 (Glioma) : In U251 cells, transfection of a miR-128 inhibitor ( 50 nmol/L ) prevented the overexpression of miR-128 by Rh2, and significantly blunted Rh2 induced cytotoxicity, apoptosis, caspase 3 activation, transcriptional activation of E2F3a , a miR-128 target gene, as well as E2F3a protein expression