◀ Back to AKT2

AKT2 — CCL2

Text-mined interactions from Literome

Murao et al., Biochem Biophys Res Commun 2000 : Constitutively active form of Akt/PKB induces transcription of the MCP-1 gene, and cotransfection of dominant negative Akt/PKB suppressed the activation of the MCP-1 promoter induced by TNF-alpha
Bian et al., Invest Ophthalmol Vis Sci 2004 : Differential involvement of phosphoinositide 3-kinase/Akt in human RPE MCP-1 and IL-8 expression
Strizzi et al., J Cell Sci 2005 (Mammary Neoplasms, Animal) : Treating EpH4/Cripto-1 or HC-11/Cripto-1 mammary cells with exogenous soluble Netrin-1 resulted in increased expression of E-cadherin and UNC5H1, decreased expression of vimentin and decreased activation of Akt as determined by western blotting
Harvey et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : The IFN-gamma induced activity of the MCP-1 gene promoter and an artificial promoter containing STAT1 responsive elements was inhibited by expression of dominant negative forms of JAK-1 and -2, STAT1, CK2, and AKT
Kleibeuker et al., J Neurochem 2008 : Increased GRK2 inhibited CCL2 induced Akt phosphorylation at Thr308 and Ser473 as well as pPDK-1 translocation ... We found that GRK2 kinase activity was not required to decrease chemokine induced ERK1/2 phosphorylation, whereas regulation of CCL2 induced Akt phosphorylation did require an active GRK2 kinase domain
Yao et al., J Neurosci 2009 : Blocking TRPC channels and specific downregulation of TRPC channels 1 and 5 resulted in suppression of CCL2 induced ERK/CREB activation but not Akt/NF-kappaB activation
Seki et al., Hepatology 2009 (Liver Cirrhosis) : In vitro experiments demonstrated that HSCs deficient in CCR2 ( -/- ) or its downstream mediator p47phox ( -/- ) did not display extracellular signal regulated kinase and AKT phosphorylation, chemotaxis, or reactive oxygen species production in response to MCP-1 , MCP-2, and MCP-3
Mizutani et al., Anticancer Res 2009 (Prostatic Neoplasms) : Possible mechanism of CCL2 induced Akt activation in prostate cancer cells ... The purpose of this study was to determine the mechanism by which CCL2 activates Akt in prostate cancer PC-3 cell line ... CCL2 induced phosphorylation of Akt was inhibited by pertussis toxin and the adenylyl cyclase inhibitor SQ22536 ... The results suggest that CCL2 induced Akt phosphorylation is mediated by the Galphai complex and adenylyl cyclase ... This is the first study that demonstrates a direct involvement of adenylyl cyclase in CCL2 induced Akt phosphorylation
Boomsma et al., PloS one 2012 : MCP-1 reduced the level of phospho-Akt ( Ser473 ) while having no effect on the other two ; the PI 3-K? inhibitor did not alter the MCP-1 effect