Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

CCL27 — TNF

Text-mined interactions from Literome

Homey et al., Nat Med 2002 (Inflammation) : Tumor necrosis factor-alpha and interleukin-1beta induced CCL27 production whereas the glucocorticosteroid clobetasol propionate suppressed it
Vestergaard et al., Exp Dermatol 2004 (Dermatitis, Atopic) : TARC augments TNF-alpha induced CTACK production in keratinocytes ... We found that CTACK can be induced in cultured human keratinocytes by tumor necrosis factor-alpha (TNF-alpha) , but not by TARC alone
Kanda et al., J Allergy Clin Immunol 2004 : TNF-alpha increased CCL27 secretion and mRNA levels in parallel to NF-kappaB activity in keratinocytes ... NF-kappaB p50 or p65 antisense oligonucleotides suppressed TNF-alpha induced CCL27 production, indicating the requirement of NF-kappaB for CCL27 production ... PGE ( 2 ), EP2, or EP3 agonists reduced TNF-alpha induced CCL27 secretion and mRNA levels in parallel to NF-kappaB activity and CCL2, CCL5, CXCL8, and CXCL10 mRNA levels
Vestergaard et al., Cytokine 2005 : Tumor necrosis factor-alpha induced CTACK/CCL27 ( cutaneous T-cell attracting chemokine ) production in keratinocytes is controlled by nuclear factor kappaB ... CCL27 can be induced in cultured keratinocytes by tumor necrosis factor (TNF)-alpha , which is also known to induce activity of the transcription factor NF-kappaB ... We show here that inhibition of NF-kappaB with the non-specific NF-kappaB inhibitors SSC ( sodium salicylate ), DCIC ( 3,4-dichloroisocoumarin ) and PAO ( phenylarsine oxide ) results in a downregulation of TNF-alpha induced CCL27 production ... Inhibition of either p50 or p65 production with antisense oligonucleotides resulted in a significant downregulation of TNF-alpha induced CCL27 production
Kanda et al., J Allergy Clin Immunol 2005 : IL-17 suppresses TNF-alpha induced CCL27 production through induction of COX-2 in human keratinocytes ... We examined the in vitro effects of IL-17 on TNF-alpha induced CCL27 production in human keratinocytes ... IL-17 suppressed TNF-alpha induced CCL27 secretion and mRNA expression and NF-kappaB activity in keratinocytes ... IL-17 might suppress TNF-alpha induced CCL27 production by inhibiting NF-kappaB through induction of COX-2
Kanda et al., Biochem Pharmacol 2006 : Suppressive effects of antimycotics on tumor necrosis factor-alpha induced CCL27 , CCL2, and CCL5 production in human keratinocytes ... We examined in vitro effects of antimycotics on TNF-alpha induced CCL27 , CCL2, and CCL5 production in human keratinocytes ... Antimycotics ketoconazole and terbinafine hydrochloride suppressed TNF-alpha induced CCL27 , CCL2, and CCL5 secretion and mRNA expression in keratinocytes in parallel to the inhibition of NF-kappaB activity while fluconazole was ineffective ... Anti-prostaglandin E2 ( PGE2 ) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on TNF-alpha induced NF-kappaB activity and CCL27 , CCL2, and CCL5 production, indicating the involvement of endogenous PGE2 in the inhibitory effects ... Carboxyheptyl imidazole also suppressed TNF-alpha induced NF-kappaB activity and CCL27 , CCL2, and CCL5 production ... These results suggest that ketoconazole and terbinafine hydrochloride may suppress TNF-alpha induced NF-kappaB activity and CCL27 , CCL2, and CCL5 production by increasing PGE2 release from keratinocytes
Kanda et al., Clin Exp Allergy 2007 : However, LTB ( 4 ) potently enhanced TNF-alpha induced CCL27 secretion and mRNA expression and NF-kappaB activity ... These results suggest that LTB ( 4 ) may enhance TNF-alpha induced CCL27 production by activating NF-kappaB via the BLT1/G ( i/o ) /PI3K/ERK pathway in human keratinocytes