Gene interactions and pathways from curated databases and text-mining

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CCR1 — CXCL2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Schwartzkopff et al., Innate Immun 2012 (Inflammation) : We report that the platelet derived CXC chemokine ligand 4 ( CXCL4 ), a known activator of human monocytes, induces down-regulation of CC chemokine receptors (CCR) 1 , -2, and -5, resulting in drastic impairment of monocyte chemotactic migration towards cognate CC chemokine ligands (CCL) for these receptors ... Interestingly, CXCL4 mediated down-regulation of CCR1 , CCR2 and CCR5 was strongly dependent on the chemokine 's ability to stimulate autocrine/paracrine release of TNF-a ... Interestingly, CXCL4 mediated down-regulation of CCR1, CCR2 and CCR5 was strongly dependent on the chemokine 's ability to stimulate autocrine/paracrine release of TNF-a ... Culture supernatants of CXCL4 stimulated monocytes as well as chemokine enriched preparations thereof reproduced CXCL4 induced CCR down-regulation
Lee et al., J Immunol 2012 : CCR1 mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Ga ( 14/16 ) signaling and IL-6 release