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CCR5 — IL12A

Text-mined interactions from Literome

Biasin et al., J Infect Dis 2000 : However, interleukin (IL)-6, IL-10, IL-12 , interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV infected women ; CCR5 and CXCR4 mRNA were augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV infected women ; HIV-specific IFN-gamma secreting cells were detected in vaginal washes of ESN and HIV infected women ; and phenotypic alterations were present in PBMC of ESN women
Iwasaki et al., Eur J Immunol 2001 (Calcium Signaling) : A critical role for IL-12 in CCR5 induction on T cell receptor triggered mouse CD4 ( + ) and CD8 ( + ) T cells ... However, TCR triggered T cells expressed IL-12 receptor, and stimulation with recombinant IL-12 resulted in high levels of CCR5 expression on both CD4 ( + ) and CD8 ( + ) T cells ... Stimulation of these CCR5 positive T cells with the relevant chemokine MIP-1 alpha elicited Ca ( 2+ ) influx, showing that IL-12 induced CCR5 is functional ... These results indicate a critical role for IL-12 in the induction of CCR5 on TCR triggered T cells
Mukai et al., J Leukoc Biol 2001 : These results indicate that IL-12 plays a critical role in CCR5 expression on Th1 cells and consequently contributes to CCR5 mediated activation of LFA-1 molecules
Iwasaki et al., J Immunol 2001 : A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5 ... In contrast, TCR triggered STAT4 ( -/- ) T cells failed to express CCR5 in response to IL-12
Yang et al., J Clin Immunol 2001 : However, when purified T cells instead of unfractionated PBL were stimulated with anti-CD3/CD28 and then exposed to IL-12 or IFN-alpha, CCR5 expression was induced by IL-12 but not by IFN-alpha ... However, when purified T cells instead of unfractionated PBL were stimulated with anti-CD3/CD28 and then exposed to IL-12 or IFN-alpha, CCR5 expression was induced by IL-12 but not by IFN-alpha
Aliberti et al., Mol Immunol 2002 : Our findings indicate that the potent IL-12 response observed is highly dependent on both the chemokine receptor CCR5 and G ( i ) -protein coupled signaling
Nakajima et al., Eur J Immunol 2002 : The induction of another Th1 chemokine receptor CCR5 absolutely required IL-12 stimulation and STAT4 involvement
Losana et al., J Leukoc Biol 2002 (HIV Infections) : IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytes
Rodriguez-Galán et al., J Immunol 2005 : In contrast, IL-18-plus-IL-12 specifically induced CCR5 expression
Zhu et al., J Pharmacol Exp Ther 2006 (Encephalomyelitis, Autoimmune, Experimental) : In vitro study also showed PSE inhibited interferon (IFN)-gamma dependent CXCR3 expression in T cells through suppressing T-cell receptor ( TCR ) ligation induced IFN-gamma production, whereas it inhibited interleukin (IL)-12 dependent CCR5 expression through suppressing IL-12 reactivity in TCR triggered T cells
Ni et al., Br J Pharmacol 2009 (Encephalomyelitis, Autoimmune, Experimental) : In addition, TAK-779 did not affect production of IL-12 by antigen presenting cells, CCR5 induction on T cells and the potential of MOG-specific T cells to transfer EAE