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CD2 — LCK
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
LCK
—
CD2
(physical association, affinity chromatography technology)
Bell et al., J Exp Med 1996*
-
IRef Biogrid Interaction:
LCK
—
CD2
(direct interaction, pull down)
Bell et al., J Exp Med 1996*
-
IRef Hprd Interaction:
LCK
—
CD2
(in vitro)
Bell et al., J Exp Med 1996*
-
IRef Hprd Interaction:
LCK
—
CD2
(in vivo)
Bell et al., J Exp Med 1996*
-
IRef Intact Interaction:
LCK
—
CD2
(phosphorylation reaction, experimental interaction detection)
Lin et al., J Biol Chem 1998*
-
IRef Ophid Interaction:
LCK
—
CD2
(aggregation, confirmational text mining)
Bell et al., J Exp Med 1996*
-
IRef Ophid Interaction:
LCK
—
CD2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
STRING interaction:
LCK
—
CD2
(interaction, mapped from kegg_pathways)
-
STRING interaction:
CD2
—
LCK
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Danielian et al., Eur J Immunol 1992
:
Both T cell receptor (TcR)-CD3 complex and
CD2 increase the tyrosine kinase activity of
p56lck ...
CD2 can
mediate TcR-CD3 independent and CD45 dependent activation of
p56lck ... Therefore, to test directly the role of TcR-CD3 in
CD2 induced activation of
p56lck , we utilized mutant variants of the Jurkat cell line lacking in cell surface TcR-CD3 ... We found that cell surface expression of TcR-CD3 is not required for the
activation of
p56lck via
CD2 but is necessary for the appearance of the reduced-electrophoretic-mobility form of p56lck observed after CD2 triggering
Bell et al., J Exp Med 1996
:
We demonstrate that CD2 and p56lck associate when coexpressed in nonlymphoid cells, that this association requires the cytoplasmic domain of CD2, and that the SH3 domain of
p56lck mediates its interactions with
CD2
King et al., Int Immunol 1996
:
With the use of different Jurkat cell mutants it was demonstrated that
CD2 mediated activation of EMT
required expression of
LCK , but not require surface expression of the CD3 zeta chain
Henning et al., J Exp Med 1998
:
Again,
p56lck can not
prevent expression of
CD2 when expressed on a Rho- background