Gene interactions and pathways from curated databases and text-mining

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CD274 — NPM1

Text-mined interactions from Literome

Marzec et al., Proc Natl Acad Sci U S A 2008 (Lymphoma, T-Cell) : Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 ( PD-L1, B7-H1 ) ... The CD274 expression is strictly dependent on the expression and enzymatic activity of NPM/ALK , as demonstrated by inhibition of the NPM/ALK function in ALK+TCL cells by the small molecule ALK inhibitor CEP-14083 and by documenting CD274 expression in IL-3 depleted BaF3 cells transfected with the wild-type NPM/ALK, but not the kinase-inactive NPM/ALK K210R mutant or empty vector alone ... NPM/ALK induces CD274 expression by activating its key signal transmitter, transcription factor STAT3
Yamamoto et al., Cancer Sci 2009 (Hodgkin Disease...) : The involvement of NPM/ALK in B7-H1 expression was also demonstrated by introducing the construct into human non-ALCL lymphoid cell lines, which resulted in B7-H1 expression