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CD274 — NPM1
Text-mined interactions from Literome
Marzec et al., Proc Natl Acad Sci U S A 2008
(Lymphoma, T-Cell) :
Oncogenic kinase
NPM/ALK induces through STAT3 expression of immunosuppressive protein
CD274 ( PD-L1, B7-H1 ) ... The
CD274 expression is strictly
dependent on the expression and enzymatic activity of
NPM/ALK , as demonstrated by inhibition of the NPM/ALK function in ALK+TCL cells by the small molecule ALK inhibitor CEP-14083 and by documenting CD274 expression in IL-3 depleted BaF3 cells transfected with the wild-type NPM/ALK, but not the kinase-inactive NPM/ALK K210R mutant or empty vector alone ...
NPM/ALK induces
CD274 expression by activating its key signal transmitter, transcription factor STAT3
Yamamoto et al., Cancer Sci 2009
(Hodgkin Disease...) :
The
involvement of
NPM/ALK in
B7-H1 expression was also demonstrated by introducing the construct into human non-ALCL lymphoid cell lines, which resulted in B7-H1 expression