◀ Back to TGFB1
CD36 — TGFB1
Text-mined interactions from Literome
Yehualaeshet et al., Am J Pathol 1999
:
These findings suggest that activation of
L-TGF-beta1 by plasmin occurs at the cell surface of activated alveolar macrophages and
requires a
TSP-1/CD36 interaction
Han et al., J Biol Chem 2000
:
In this study, we investigated the
effect of
transforming growth factor-beta1 ( TGF-beta1 ) and TGF-beta2 on the expression of
CD36 in macrophages ...
TGF-beta1/TGF-beta2 also
inhibited CD36 mRNA expression induced by oxidized low density lipoprotein and 15-deoxyDelta ( 12,14 ) prostaglandin J ( 2 ), a peroxisome proliferator activated receptor ( PPAR)-gamma ligand, suggesting that the TGF-beta1/TGF-beta2 down-regulated CD36 expression by inactivating PPAR-gamma mediated signaling
Minami et al., Biochem Biophys Res Commun 2000
:
On the other hand,
transforming growth factor (TGF)-beta(1) , which plays crucial roles in vascular remodeling and the pathogenesis of atherosclerosis, has been shown to
inhibit expression of class A scavenger receptors and
CD36 in macrophages
Wang et al., Respir Res 2009
(Disease Models, Animal...) :
Silencing
CD36 gene expression
results in the inhibition of
latent-TGF-beta1 activation and suppression of silica induced lung fibrosis in the rat ... The lentiviral vector ( Lv-shCD36 ) silenced expression of
CD36 in alveolar macrophages ( AMs ) obtained from bronchoalveolar lavage fluid ( BALF ) and the activation of
L-TGF-beta1 in the BALF was
inhibited by Lv-shCD36 ... These results indicate that silencing expression of
CD36 can
result in the inhibition of
L-TGF-beta1 activation in a rat silicosis model, thus further preventing the development of silica induced lung fibrosis