Mustelin et al., Science 1990
:
At doses that inhibited TPK activity and tyrosine phosphorylation of the TCR zeta subunit, but not phospholipase C activity, genistein prevented TCR-CD3 mediated phospholipase C activation, interleukin-2 receptor expression, and T cell proliferation
Verwilghen et al., J Immunol 1993
:
CD5/CD28 ligation induced production of TNF-alpha, but not of IL-4 , and did not induce modulation of the TCR/CD3 complex