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CD40 — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CD40 → IFNG (increases)
  Evidence: IFN-, a cytokine expressed early during atherogenesis, potently induces CD40/CD40L expression.7?11
• OpenBEL Selventa BEL large corpus: CD40 → IFNG (increases) D'Aversa et al., Am J Pathol 2002*
  Evidence: Treatment of human fetal microglial cells with 100 U/ml IFN-gamma for 36 hours up-regulated CD40 expression.
• OpenBEL Selventa BEL large corpus: CD40 → IFNG (increases)
  Evidence: In the presence of pro-inflammatory cytokines such as tumor necrosis factor-? (TNF-?) and/or interferon-gamma (IFN-G), endothelial cell CD40 expression is markedly enhanced [6]. These cytokines, especially when combined, also induce CD40 expression in rat vascular SMC [7].
• OpenBEL Selventa BEL large corpus: CD40 → IFNG (increases)
  Evidence: TNF and IFN-g were found to be the most effective at enhancing CD40 expression, producing about a 3-fold increase in CD40 expression after 24 h (Fig. 1). IFN-beta and IL-1a also increased CD40 expression, although somewhat less effectively than TNF or IFN-g.

Text-mined interactions from Literome

von Leoprechting et al., Cancer Res 1999 (Melanoma) : CD40 expression could be enhanced in CD40 positive MM by stimulation with IFN-gamma and tumor necrosis factor-alpha but not by interleukin (IL)-1beta or CD40 triggering
Harigai et al., J Rheumatol 1999 (Arthritis, Rheumatoid) : IL-10 exerted inhibitory effects on both CD40 ligation induced and CD40 ligation plus IFN-gamma induced TNF-alpha production by ST cells
Subauste et al., J Immunol 1999 (Chronic Disease...) : CD40-CD40L signaling was required for optimal T cell production of IFN-gamma in response to T. gondii
Kooy et al., J Pathol 1999 (Carcinoma, Basal Cell...) : Interferon-gamma induced ICAM-1 and CD40 expression, complete lack of HLA-DR and CD80 ( B7.1 ), and inconsistent HLA-ABC expression in basal cell carcinoma : a possible role for interleukin-10 ?
Méndez-Samperio et al., Scand J Immunol 1999 : Interleukin-12 regulates the production of Bacille Calmette-Guérin induced interferon-gamma from human cells in a CD40 dependent manner ... In this study, we investigated the capacity of the Bacille Calmette-Guérin ( BCG ) strain of Mycobacterium bovis to induce the production of interferon-gamma through IL-12 and/or CD40 costimulation from human cells ... Together, these studies are the first to demonstrate that BCG induced IFN-gamma production by human cells appears to be mediated by IL-12 in a CD40 dependent manner and suggest that CD40-CD40L activation may be a critical mediator in regulating the immune response to stimulation with BCG
Tan et al., J Neuroimmunol 1999 (Multiple Sclerosis) : Activation of microglia by ligation of CD40 in the presence of IFN-gamma results in cultured cortical neuronal injury, which is markedly attenuated by blockade of the CD40 pathway or neutralization of TNF-alpha
Sugiura et al., J Immunol 2000 (Dermatomyositis...) : Although cultured human myoblasts ( SkMC 2859 ) did not express CD40 constitutively, IFN-gamma induced CD40 expression in a dose dependent manner
Albanesi et al., J Invest Dermatol 2000 (Dermatitis, Allergic Contact...) : Moreover, interleukin-17 and interleukin-4 enhanced interferon-gamma induced expression of intercellular adhesion molecule 1, but not CD40 , on keratinocytes
Subauste et al., J Immunol 2000 : IFN-gamma production in response to DC infected with viable parasites required CD28 and CD40 ligand (CD40L) signaling
Willermain et al., Invest Ophthalmol Vis Sci 2000 : Although interferongamma enhanced IL-6 and IL-8 production, CD40 triggering of IFNgamma activated hRPE cells did not induce IL-12 secretion
Nguyen et al., J Immunol 2000 : IL-4 activated STAT-6 inhibits IFN-gamma induced CD40 gene expression in macrophages/microglia ... We have previously shown that IFN-gamma is the most potent inducer of CD40 expression by macrophages and microglia ... In this report, we describe the molecular mechanisms by which IL-4 inhibits IFN-gamma induced CD40 expression ... IL-4 suppresses IFN-gamma induced CD40 gene expression in both macrophages and microglia, and such inhibition is dependent on the activation of STAT-6 ... Furthermore, IL-4 inhibition of IFN-gamma induced CD40 expression is specific, since IL-4 does not inhibit IFN-gamma induced IFN-responsive factor-1 gene expression ... Site directed mutagenesis studies demonstrate that two STAT binding sites, named proximal and distal IFN-gamma activated sequences, in the human CD40 promoter are important for IL-4 inhibition of IFN-gamma induced CD40 promoter activity ... These results suggest that IL-4 inhibition of IFN-gamma induced CD40 gene expression is mediated by direct STAT-6 binding to the CD40 promoter
Magistrelli et al., Biochem Biophys Res Commun 2001 : The activation of monocytes by IFNgamma (i) induces the preferential expression of the transcript encoding for the membrane form and ( ii ) increases the expression of CD86 and of the accessory molecules CD40 , CD49d and CD54
Schwabe et al., J Immunol 2001 : CD40 expression is strongly enhanced by IFN-gamma
Subauste et al., J Infect Dis 2001 (AIDS-Related Opportunistic Infections...) : CD40LT restored T. gondii- and CMV triggered IFN-gamma secretion by T cells and PBMC from HIV infected patients with a CD4 cell count > 200 cells/microL
Kitagawa et al., J Rheumatol 2001 (Arthritis, Rheumatoid) : We examined the effects of IFN-gamma , tumor necrosis factor-alpha (TNF-alpha), and granulocyte-macrophage colony stimulating factor ( GM-CSF ) on CD40 expression on CD68+ synovial macrophage-lineage cells ( SMC ) ... The effects of IFN-gamma on CD40 expression ( EC50 = 127.4 U/ml ) were observed at a concentration 19 times lower than the effects on IL-12 production ( EC50 = 6.8 U/ml )
Li et al., Chin Med J (Engl) 2001 (Graves Disease) : oPRL could antagonize the stimulation of CD40 expressions by IFN-gamma and the inhibition by IL-4 on both groups of thyrocytes
Zou et al., Eur J Immunol 2001 (Adenovirus Infections, Human) : PDC type I interferons inhibited MDC differentiation and function ( reduced IL-12 secretion, IFN-gamma induction , MLR and CD40 expression, and increased CD1a ( + ) CD14 ( + ) cells )
Mendel et al., J Neuroimmunol 2002 (Disease Models, Animal...) : We demonstrate that the proliferative response and IFN-gamma production by a fully differentiated T cell line specific for myelin oligodendrocyte glycoprotein are completely independent of IL-12 and CD40/CD40L interactions
Wagner et al., Blood 2002 : In contrast, CD40 expression in response to IFN-gamma stimulation was sensitive to neutralization of STAT-1 only
Iwata et al., Invest Ophthalmol Vis Sci 2002 : IFN-gamma enhanced CD40 expression on both cell types
Terrazzano et al., J Leukoc Biol 2002 : Differential involvement of CD40 , CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors
Wesemann et al., J Immunol 2002 : We have previously shown that IFN-gamma induces CD40 expression in macrophages and microglia ... We show that ectopic expression of SOCS-1 abrogates IFN-gamma induced CD40 protein expression, mRNA levels, and promoter activity ... We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation
Lu et al., Pigment Cell Res 2002 : Moreover, we report for the first time CD 40 expression by melanocytes can be up-regulated by interferon-gamma (IFN-gamma) stimulation
Samten et al., J Immunol 2003 : CD40LT induced IFN-gamma production was dependent on production of IL-12 and IL-18, but did not require IL-15
Uhm et al., Rheumatology (Oxford) 2003 (Acute Disease...) : CD40 expression of cultured mesangial cells was up-regulated by IFN-gamma , but was not down-regulated in the presence of the Th2 cytokines IL-4 and IL-10
Melichar et al., Int J Gynecol Cancer 2003 (Carcinoma...) : Soluble CD40Lt did not enhance MO/MA cytotoxic activity, and inhibited IFN-gamma or IL-2 induced cytoxicity
Galy et al., J Immunol 1992 : IL-1 alpha, TNF-alpha, IFN-gamma , but not IL-4, significantly up-regulated the membrane expression of CD40 on cultured TEC
Kaufman et al., J Immunol 2004 (Pulmonary Fibrosis) : Interestingly, CD40L expression is down-regulated by IFN-gamma , a type 1 cytokine with antiscarring properties, and is up-regulated by the profibrogenic type 2 cytokine IL-13
Cagnoni et al., J Immunol 2004 (Asthma) : Our data show that CD40 is up-regulated by IFN-beta and IFN-gamma , its ligation increases the surface expression of CD54 and CD106 and it may stimulate the release of IL-6 and IL-8
Jeurissen et al., Eur J Immunol 2004 (Hypergammaglobulinemia) : Furthermore, we showed that caps-PS induce production of IL-4, IL-6, IL-10, and IFN-gamma , and that this enhanced production was inhibited by blocking the CD40-CD40L interaction
Gutzmer et al., Immunology 2004 : After up-regulation of the C3aR by IFN-alpha+ IFN-gamma , C3a significantly up-regulated the surface expression of CD54, CD83 and CD86, but not of CD40 , CD80 or human leucocyte antigen ( HLA ) -DR. C3a had no effect on the production of interleukin (IL)-10 or IL-12p70, or on the capacity of MoDC to stimulate autologous T-cell proliferation
Zhou et al., Int Immunopharmacol 2004 : Although its precise mode of action is still unclear, several biological effects have been described including inhibition of IFN-gamma induced CD40 expression on monocytes ... IFN-gamma induced CD40 transcription has been shown to be mediated by STAT1alpha dimers ( p91/p84 ) which, after nuclear translocation, bind to GAS elements present in the promoter of IFN-gamma responsive genes
Han et al., Immunology 2004 : However, interferon-gamma up-regulated CD40 on adult monocytes but not on cord monocytes
Scott et al., Clin Exp Immunol 2004 (Sepsis) : CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent
Nunes et al., Microbes Infect 2005 (Genetic Predisposition to Disease...) : In the presence of IFN-gamma , CD40 engagement induced Leishmania killing by macrophages from both strains
Shah et al., Int J Cancer 2005 (Neoplasms, Experimental) : IFN-gamma secretion in splenocyte : tumor co-cultures of tumor challenged BCDM was inhibited by WT but not CD40 ( -/- ) B cells indicating that B cells may inhibit anti-tumor T ( H ) 1 cytokine responses in a CD40 dependent manner
la Sala et al., J Immunol 2005 : This effect was due neither to a down-regulation of TLR4 or IFN-gamma receptor on the cell surface nor to interference with IFN-gamma signaling, because IFN-gamma induced up-regulation of HLA-DR and CD40 were unaffected
Atochina et al., Clin Diagn Lab Immunol 2005 : As part of the cell-cell contact mechanism, we determined that CD40-CD40L interaction was critical for IFN-gamma secretion by NK cells, as the addition of anti-CD40L antibodies to the coculture blocked IFN-gamma production
Ehrhart et al., Journal of neuroinflammation 2005 : We found that the selective stimulation of cannabinoid receptor CB2 by JWH-015 suppressed IFN-gamma induced CD40 expression
Zhou et al., Infect Immun 2006 (Cryptococcosis...) : Depletion of CD4+ T cells did not affect the increased serum IFN-gamma levels induced by anti-CD40 and IL-2 treatment and, importantly, did not affect the antifungal effect of combination therapy
Yan et al., Clin Experiment Ophthalmol 2006 (Graves Ophthalmopathy) : Triptolide 0.01 microg/L had little effect on IFN-gamma induced HLA-DR, ICAM-1 and CD40 amounts, as well as HA synthesis
Blachère et al., J Immunol 2006 : Concerning the interaction between CD4 ( + ) T cells and DCs, we tested the hypothesis that CD40 engagement on DCs is critical for IL-12p70 ( IL-12 ) production and subsequent stimulation of IFN-gamma release by CD8 ( + ) T cells
Geraldes et al., Cardiovasc Res 2006 : Treatment of PAEC with antisense oligomers targeting ERalpha mRNA attenuated the ability of 17betaE to inhibit the IFN-gamma induced CD40 and CD40L protein expression ... In summary, 17betaE binding to ERalpha blocked IFN-gamma induced Stat1 phosphorylation, CD40 and CD40L protein expression, and neutrophil adhesion onto ECs
Hewitson et al., J Immunol 2006 (Helminthiasis) : CD40/CD154 interactions are required for the optimal maturation of skin derived APCs and the induction of helminth-specific IFN-gamma but not IL-4
Faith et al., Am J Respir Cell Mol Biol 2007 (Lung Neoplasms) : Ligation of CD40 on plasmacytoid-DC combined with exposure to CpG 2216 also strongly enhanced IFN-gamma production
Muralimohan et al., Cell Immunol 2006 : Nonetheless, pDCs strictly required IFNgamma for upregulation of CD86 and CD40 , but cDCs did not depend upon IFNgamma for activation
D'Alimonte et al., J Immunol 2007 : Guanosine effects were mediated by an increased phosphorylation of Akt, a PI3K downstream effector, as well as of ERK1/2 and p38 in the MAPK system, because culture pretreatment with selective ERK1/2, p38 MAPK, and PI3K antagonists ( U0126, SB203580, or LY294002, respectively ) counteracted guanosine inhibition on IFN-gamma/TNF-alpha induced CD40 expression and function as well as on STAT-1alpha or NF-kappaB nuclear translocation
De L Karlson et al., Clin Exp Immunol 2007 (Colitis) : Proinflammatory cytokine synthesis by mucosal fibroblasts from mouse colitis is enhanced by interferon-gamma mediated up-regulation of CD40 signalling
Chen et al., J Immunol 2007 : IFN-gamma additionally increased the expression of CD40 by microglial cells and soluble CD40L significantly promoted cell responses to IFN-gamma during a 6-h incubation period by enhancing the activation of MAPK and IkappaB-alpha signaling pathways
Lee et al., J Leukoc Biol 2007 : Simvastatin inhibits IFN-gamma induced CD40 gene expression by suppressing STAT-1alpha ... IFN-gamma induced CD40 expression involves activation of STAT-1alpha as well as NF-kappaB activation through an autocrine response to IFN-gamma induced TNF-alpha production ... Herein, we describe that simvastatin ( SS ) inhibits IFN-gamma induced CD40 expression via the suppression of STAT-1alpha expression ... Collectively, these data indicate that SS inhibits IFN-gamma induced CD40 expression by suppression of STAT-1alpha, and altering transcriptional events at the CD40 promoter
Starke et al., Nephron. Experimental nephrology 2007 : Interestingly, TGF-beta treatment of TECs increased the constitutive and IFN-gamma induced CD40 expression
Waeckerle-Men et al., Kidney Blood Press Res 2007 : Stimulation of TEC with IFN-beta or IFN-gamma , but not other tested cytokines, enhanced the expression of PD-L1, ICOS-L and CD40
Wu et al., Cell Immunol 2008 (Carcinoma, Renal Cell...) : CD40 expression could be induced by interferon-gamma (IFN-gamma)
Rezai-Zadeh et al., Journal of neuroinflammation 2008 (Encephalitis) : For example, it is well known that the activation of the signal transducer and activator of transcription ( STAT ) signaling pathway plays a central role in interferon-gamma (IFN-gamma) induced microglial CD40 expression ... We and others have previously reported that microglial CD40 expression is significantly induced by IFN-gamma and amyloid-beta ( A beta ) peptide ... Apigenin and luteolin concentration-dependently suppressed IFN-gamma induced CD40 expression
Li et al., Int Immunopharmacol 2009 (Atherosclerosis) : We found that DHEA inhibited IFN-gamma induced expression of CD40 and CD40L in a dose dependent manner
Tian et al., Zhonghua Xin Xue Guan Bing Za Zhi 2008 (Acute Coronary Syndrome...) : To investigate the expression levels of CD40, sCD40L, hs-CRP, WBC in acute coronary syndrome (ACS) patients and the association between CD40-1C/T single nucleotide polymorphism and risk of ACS in Han Chinese, moreover, the regulatory effects of IFN-gamma and fluvastatin on the expression of CD40 in peripheral blood mononuclear cell ( PBMNC ) were also observed ... CD40 production increased after 24 h culturing and the CD40 levels were significantly higher in subjects with CC genotype than that in subjects with CT or TT genotype [ CC : ( 14.78 +/- 4.56 ) MFI, CT : ( 11.98 +/- 4.12 ) MFI, TT : ( 9.86 +/- 3.83 ) MFI, P < 0.05 ]. IFN-gamma further increased PBMNC CD40 expressions in all subjects after culturing for 24 h and fluvastatin equally inhibited IFN-gamma induced PBMNC CD40 expression from various genotypes ( CC, CT, TT was 30.3 %, 26.3 %, 29.3 % respectively, all P > 0.05 )
Wu et al., Biochem Biophys Res Commun 2009 : In addition, LPS exposure resulted in elevated interferon gamma (IFNgamma) levels in the medium of PBMCs. Neutralization of IFNgamma and IFNgamma receptor using specific antibodies blocked LPS induced CD40 expression by 44 % and 37 %, respectively
Krimmer et al., Allergy 2009 (Asthma) : The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expression ... Interferon-gamma and TNF-alpha synergistically increased CD40 expression to a greater extent on asthmatic than on nonasthmatic ASM ... TNF-alpha and IFN-gamma induced CD40 via nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-3 in both cell types and modulated OX40L via NF-kappaB and c-Jun N terminal kinase in nonasthmatic cells ... IFN-gamma may regulate ASM pro-inflammatory actions by differentially modulating ASM CD40 and OX40L expression
Lin et al., Journal of neuroinflammation 2009 : Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma induced CD40 in murine microglia
Lin et al., J Neurochem 2009 : Context dependent IL-6 potentiation of interferon- gamma induced IL-12 secretion and CD40 expression in murine microglia ... For instance, IFNgamma induced expression of the co-stimulatory molecule, CD40 was dependent on sIL-6R administration ... In granulocyte-macrophage colony stimulating factor ( GMCSF ) -induced dendritic cell-like microglia, IL-6/sIL-6R and IFNgamma stimulated an even greater increase in CD40 expression compared with primary microglia
Borcherding et al., Am J Pathol 2010 (Inflammatory Bowel Diseases) : CD40 ligation by CD40L transfected murine fibroblasts or soluble CD40L increased the secretion of IL-8 in IFN-gamma pretreated HT29 cells
Bihl et al., J Immunol 2010 (Leishmaniasis, Cutaneous) : We show that early IFN-gamma secretion by NK cells is controlled by IL-2 and IL-12 and is dependent on CD40/CD40L interaction
Yellin et al., J Exp Med 1995 : Moreover, human umbilical vein endothelial cells ( HUVEC ) express CD40 in vitro, and recombinant interferon gamma induces HUVEC CD40 upregulation
Kone et al., Am J Physiol 1995 : LPS + interferon-gamma (IF-gamma) promoted a time dependent increase in nitrite ( a NO metabolite ) and iNOS mRNA and the appearance of NF-kappa B p50 and p65 in nuclear protein extracts
Ramsdell et al., J Immunol 1994 : In addition to proliferation, CD40L induces lectin mediated cytolytic activity in thymic gamma delta T cells as well as the production of IFN-gamma and TNF-alpha
Hutchins et al., Int J Cancer 1994 (Breast Neoplasms) : Interferon (IFN)gamma up-regulated the expression of ICAM-I ( CD54 ) in all the cell lines and coordinately up-regulated both CD54 and CD40 expression in T47D
Burdin et al., J Immunol 1995 : First, both CD40 and Ag receptor ( AgR ) cross linking induced purified tonsillar human B lymphocytes to secrete the same pattern of cytokines, including IL-1 beta, IL-6, IL-10, granulocyte-macrophage-CSF, and TNF-alpha, whereas IL-1 alpha, IL-2, IL-3, IL-4, IL-5, IL-7, granulocyte (G)-CSF, or IFN-gamma were not detected
Yellin et al., J Leukoc Biol 1995 (Arthritis, Rheumatoid...) : Fibroblast CD40 expression declines with increasing time in culture and recombinant interferon-gamma ( rINF-gamma ) induces fibroblast CD40 up-regulation
Castro et al., Eur J Cell Biol 1996 : They express ICAM-1, VCAM-1 and CD40 both constitutively and in inducible forms and are induced by IFN-gamma to express major histocompatibility complex class II antigens
Drew et al., J Interferon Cytokine Res 1995 : We demonstrated here that TNF-alpha induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence ( ICS )
Francisco et al., J Immunol 1996 (Leukemia, Monocytic, Acute) : This sensitization could not be explained simply by the two- to threefold increase in cell surface CD40 expression induced by IFN-gamma since TNF-alpha or the combination of TNF-alpha and IL-6 gave similar increases in CD40 expression but did not sensitize the cells to the immunotoxin
Cella et al., J Exp Med 1996 : These effects of CD40 ligation result in an increased capacity of DCs to trigger proliferative responses and IFN-gamma production by T cells
Peng et al., Eur J Immunol 1996 : In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells ... In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells
Vingerhoets et al., Clin Exp Immunol 1997 (HIV Infections) : Anti-CD3 combined with CD80 or CD86 induced a mixed Th1/Th2-type cytokine profile in both CD4+ and CD8+ T cells from controls, whereas anti-CD3 plus CD40 induced only low levels of Th2-type cytokines and no interferon-gamma (IFN-gamma) in CD4+ T cells
Yoshimoto et al., Proc Natl Acad Sci U S A 1997 : Furthermore, we show that, like splenic T cells stimulated with anti-CD3, IL-12, and IL-18, B cells produced high level of IFN-gamma in response to anti-CD40 , IL-12, and IL-18
McDyer et al., J Immunol 1998 : CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28 dependent manner ... The presence of CD40T in cultures increased the production of IL-12 and IFN-gamma from PBMCs stimulated with varying amounts of PHA ... The mechanism, however, by which CD40T enhanced IFN-gamma varied according to the level of T cell activation
Metcalfe et al., J Clin Endocrinol Metab 1998 : CD40 expression was up-regulated by interleukin-1alpha and interferon-gamma , but not by TSH
Tan et al., J Immunol 1998 (Encephalomyelitis, Autoimmune, Experimental) : IFN-gamma activation up-regulated ICAM-1, VCAM-1, MHC class II, invariant chain, H2-M, CD40 , and B7-1 as determined by FACS and/or RT-PCR analyses
Nguyen et al., Eur J Immunol 1998 : Microglia constitutively express very low levels of CD40 , and IFN-gamma enhances CD40 mRNA and protein expression in these cells ... IFN-gamma induced CD40 mRNA expression is partially sensitive to the protein synthesis inhibitor puromycin, suggesting that ongoing protein synthesis is necessary for optimal induction of CD40 mRNA by IFN-gamma ... Inhibition of IFN-gamma induced CD40 mRNA levels by TGF-beta in microglia is not due to inhibition of CD40 transcription ; rather, inhibition is due to enhanced degradation of CD40 mRNA
Seko et al., Circ Res 1998 (Coxsackievirus Infections...) : The expression of CD40 on cardiac myocytes could be induced by interferon gamma in vitro
Suo et al., Brain Res 1998 (Alzheimer Disease...) : Moreover, IL-1beta and IFN-gamma synergistically increased the Abeta induced expression of CD40 and IFN-gammaR
van der Velden et al., Eur Cytokine Netw 1998 : In contrast, IFN-gamma had no effect on the release of IL-8, but it did increase the epithelial expression of ICAM-1, CD40 , and HLA class II molecules