◀ Back to TGFB1

CD44 — TGFB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CD44 → TGFB1 (increases, TGFB1 Translocation)
  Evidence: TGF-beta 1 also down-regulated CD45RB and increased CD44 expression on responsive CD8+ and CD45RBhi T cells, thereby leading to a population of T cells enriched in mature phenotype.

Text-mined interactions from Literome

Koyama et al., Int J Oncol 2000 (Adenocarcinoma, Scirrhous...) : The CD44H expression of scirrhous gastric cancer cells was significantly up-regulated by gastric fibroblast derived CM and TGF-beta1 ... These findings suggested that TGF-beta1 secreted by gastric fibroblasts up-regulated the CD44H expression of scirrhous gastric cancer cells, which resulted in the stimulation of the adhesion ability of scirrhous gastric cancer cells to the mesothelium, and increased the peritoneal dissemination potential
Takazoe et al., Clin Exp Immunol 2000 (Glomerulonephritis...) : Stimulation of NRK52E cells with IL-1 or transforming growth factor-beta 1 induced a two-to-five-fold increase in the expression of both CD44S and CD44V6
Ahrens et al., J Invest Dermatol 2001 (Melanoma) : Culture of melanoma cells in the presence of hyaluronic acid resulted in a dose dependent, CD44 mediated increase of melanoma cell proliferation and enhanced release of basic fibroblast growth factor and transforming growth factor beta 1
Cichy et al., FEBS Lett 2004 : In this study, we demonstrate that oncostatin M and transforming growth factor beta1 ( TGF-beta1 ) which stimulate hyaluronan binding to HTB58 lung epithelial derived tumor cells, also induce the release of soluble CD44
Lee et al., J Immunol 2004 (Colorectal Neoplasms...) : Modulation of NKG2D by TGF-beta1 was specific, as expression of other NK receptors, CD94/NKG2A, CD44 , CD16, 2B4, or CD56, was not affected by TGF-beta1
Ibrahim et al., Int J Gynecol Cancer 2006 (Adenocarcinoma...) : Upregulation of CD44 expression by interleukins 1, 4, and 13, transforming growth factor-beta1 , estrogen, and progestogen in human cervical adenocarcinoma cell lines ... The effects of interleukin (IL)-1alpha, IL-1beta, IL-4, IL-13, transforming growth factor (TGF)-beta1 , estrogen, and progestogen on CD44v5 expression were examined in cultures of three human cervical adenocarcinoma cell lines ( HeLa, HeLa229, and HS588T )
Kao et al., Cytokine 2009 : Gelatine zymography and immunofluorescent stain evidenced that elevated MMP-2 and MMP-9 activity and serum dependent CD44 expression and its membranous localization may contribute to TGF-beta1 activation
Simpson et al., Am J Pathol 2010 : Taken together, these results demonstrate that HA can serve as a signal integrator by facilitating TGF-beta1 mediated CD44-EGF-R-ERK interactions and ultimately fibroblast phenotype
Nakashio et al., Int J Oncol 1997 : TGF-beta 1 increased the expression of CD44H in NUGC-4 cells and in mesothelial cells, and augmented the adhesion and implantation of NUGC-4 cells to mesothelial cells accompanied by accumulation of extracellular matrix ( ECM ) components
Uhl-Steidl et al., Oncology 1995 (Carcinoma...) : Interferon-alpha, interferon-gamma, tumor necrosis factor, transforming growth factor-beta , all-trans retinoic acid and cisplatin did not affect CD44v expression
Faassen et al., J Cell Sci 1993 (Melanoma, Experimental...) : Transforming growth factor-beta 1 stimulated cell surface CD44-chondroitin sulfate proteoglycan synthesis in mouse melanoma cells, specifically through an upregulation of chondroitin sulfate production, while the expression of CD44-chondroitin sulfate proteoglycan core protein was not affected
Morris et al., In Vitro Cell Dev Biol Anim 1994 : Specific stimulation of basal lamina heparan sulfate proteoglycan in mouse uterine epithelium by Matrigel and by transforming growth factor-beta 1
Lee et al., J Immunol 1993 : TGF-beta 1 also down-regulated CD45RB and increased CD44 expression on responsive CD8+ and CD45RBhi T cells, thereby leading to a population of T cells enriched in mature phenotype
Kolm et al., Am J Physiol 1996 : High glucose induced TGF-beta 1 regulates mesangial production of heparan sulfate proteoglycan