Liu et al., Mol Cell Biol 2007
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The Skp2 degradation is mediated by Cdh1-anaphase promoting complex (APC) , as shown by depletion of Cdh1 with small interfering RNA, and by reconstitution of ubiquitylation reactions in a purified system
Chen et al., Proc Natl Acad Sci U S A 2011
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Remarkably, down-regulation of Ufd1 enhances ubiquitination and destabilization of Skp2 mediated by the anaphase promoting complex or cyclosome bound to Cdh1 ( APC/C ( Cdh1 ) ), resulting in accumulation of the cyclin dependent kinase inhibitor p27 and a concomitant cell cycle delay during the G1 phase that enables more efficient clearance of misfolded proteins