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CDC42 — EGFR
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lin et al., Methods Enzymol 2006
:
In addition, we have introduced procedures for determining the
effects of
Cdc42 and its downstream targets, in particular, ACK ( Activated Cdc42 associated Kinase ) and p85Cool-1 ( Cloned out of library ) /Pix ( for Pak-interactive exchange factor ), on
EGFR degradation
Hirsch et al., Cancer Res 2006
(Breast Neoplasms) :
In NIH3T3 fibroblasts, active
Cdc42 inhibits c-Cbl regulated
EGFR degradation to induce cellular transformation ... Here, we use two EGFR overexpressing breast cancer cell lines, MDA-MB-231 and BT20, as models to test the hypothesis that up-regulated
Cdc42 activity impairs c-Cbl mediated EGFR degradation and
contributes to
EGFR overexpression ... We show that silencing
Cdc42 significantly
reduces protein levels of
EGFR , leading to a marked reduction in cell proliferation and migration, and c-Cbl knockdown increases the levels of EGFR
Shen et al., J Biol Chem 2008
:
The role of Cdc42 in regulating E-cadherin ubiquitination and degradation is underscored by the fact that constitutively active
Cdc42 ( F28L )
increases the activity of
EGFR and Src and significantly enhances E-cadherin ubiquitination and lysosomal degradation