Gene interactions and pathways from curated databases and text-mining

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CDC45 — RAD50

Text-mined interactions from Literome

Dolan et al., Chromosoma 2004 : Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding
Hermand et al., Mol Cell 2007 : Rad26 directly binds Cdc18 and is required for Rad3 recruitment to chromatin ... Depletion of Cdc18 when DNA replication is stalled leads to release of Rad3 and Rad26 from chromatin and entry into an aberrant mitosis even though replication intermediates can still be detected