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CASP1 — CDK2

Text-mined interactions from Literome

Kim et al., Oncogene 2001 (Stomach Neoplasms) : In contrast, the suppression of caspase-3 activity inhibited the cleavage of target proteins, the activation of Cdk2 , and the induction of apoptosis
Mongay et al., J Biol Chem 2001 : Moreover, we showed that overexpression of CksHs1 inhibits CDK2 kinase activity and that additional expression of p45 ( SKP2 ) overcame this inhibition and restored CDK2 kinase activity
Morris et al., J Neurosci 2001 : However, either p53 deficiency or the inhibition of CDK activity alone inhibited Bax translocation, cytochrome c release, and caspase-3-like activation
Hiromura et al., Oncogene 2002 : Finally, we showed that caspase-3 activity was significantly reduced by inhibiting CDK2 activity with Roscovitine
Lukovic et al., Exp Cell Res 2003 : Employing direct cytofluorimetric analyses of intracellular caspase activity and colony forming assays, we now show that transient blockade of caspase dependent Cdk2 activity confers long lived sparing from death on cells otherwise triggered to die and fully replete with caspase activity
Sohn et al., Cancer Res 2006 : p21 blocks irradiation induced apoptosis downstream of mitochondria by inhibition of cyclin dependent kinase mediated caspase-9 activation
Wu et al., Planta Med 2007 : The mechanisms underlying these pharmacological effects include reduced expression of cell cycle mediators such as CDK4, cyclins D1 and A, retinoblastoma ( Rb ) and vascular endothelial growth factor receptor 1 ( VEGFR-1 ), and promotion of caspase mediated activation of CDK inhibitors p21(Cip1) and p27 ( Kip )
Wang et al., J Asian Nat Prod Res 2009 : 1 in high concentrations induced Bax, caspase-3 , and cyclin dependent kinase (CDK) inhibitor P21 expression, whereas the expressions of cyclin CDK2 , Bcl-2, and proliferating cell nuclear antigen ( PCNA ) were decreased by 1 treatment
Yang et al., Mol Med Report 2010 : The expression of cyclin D1 , cyclin dependent kinase 4 (CDK4), Bcl-2, Bcl-xL and the activation of caspase-3 were examined by Western blotting
Guo et al., Protein & cell 2011 : Ectopic expression of the dominant negative Cdk2 ( Cdk2-dn ) and a specific Cdk2 inhibitor, p21 ( WAF1/CIP1 ), effectively suppresses the loss of MMP, the release of cytochrome c, and subsequent activation of caspase-3 in paclitaxel treated cells