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CIITA — EPHB2
Text-mined interactions from Literome
Yao et al., J Immunol 2006
(MAP Kinase Signaling System) :
ERK and p38 MAPK signaling pathways negatively
regulate CIITA gene expression in dendritic cells and macrophages
Voong et al., J Biol Chem 2008
:
In contrast, inhibition of
ERK1/2 activity
had little effect on serine-to-alanine mutant forms of
CIITA ... These data suggest a model whereby
ERK1/2 mediated phosphorylation of
CIITA down-regulates CIITA activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation