Gene interactions and pathways from curated databases and text-mining

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CALM3 — CNGB1

Pathways - manually collected, often from reviews:

  • KEGG Olfactory transduction: CNGA3/CNGA4/CNGB1 → CALM1/CALM2/CALM3/CALML3/CALML5/CALML6 (protein-protein, compound)
  • KEGG Phototransduction: CALM1/CALM2/CALM3/CALML3/CALML5/CALML6 → CNGA1/CNGB1 (protein-protein, inhibition)

Text-mined interactions from Literome

Kelliher et al., Proc Natl Acad Sci U S A 2003 : Mice in which the CNGA4 gene has been deleted display defective Ca ( 2+ ) calmodulin dependent inhibition of the CNG channel , resulting in a striking reduction in adaptation of the odor induced electrophysiological response in the OSNs
Peng et al., J Biol Chem 2003 (Ion Channel Gating) : Whereas an important aspect of sensory adaptation in rod photoreceptors and olfactory receptor neurons is thought to be the regulation of cyclic nucleotide gated (CNG) channel activity by calcium-calmodulin ( Ca2+-CaM ), it is not clear that cone photoreceptor CNG channels are similarly modulated
Weitz et al., EMBO J 1998 : Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the N-terminus of the beta-subunit