Gene interactions and pathways from curated databases and text-mining

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CPOX — IL8

Text-mined interactions from Literome

Fong et al., Am J Physiol Lung Cell Mol Physiol 2000 : In this study, we tested the ability of transforming growth factor (TGF)-beta1 to stimulate IL-8 release, cyclooxygenase (COX)-2 expression and PGE ( 2 ) generation in cultured human ASM cells and explored the role of COX products and COX-2 induction on IL-8 release ... TGF-beta1 stimulated IL-8 release, COX-2 induction , and PGE ( 2 ) generation in a concentration- and time dependent manner ... These results show for the first time that TGF-beta1 stimulates IL-8 release, COX-2 induction , and PGE ( 2 ) generation in human ASM cells and that PGE ( 2 ) generation is not critical for TGF-beta1 induced IL-8 release
Moore et al., J Appl Physiol 2001 : In human cultured airway smooth muscle cells, interleukin (IL)-1 beta increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Helmersson et al., Free radical research 2005 (Cardiovascular Diseases...) : This study investigated the longitudinal association between serum selenium ( s-Se ) and a golden standard indicator of oxidative stress in vivo ( 8-iso-prostaglandin F2alpha, a major F2-isoprostane ), an indicator of cyclooxygenase (COX) mediated inflammation ( prostaglandin F2alpha ), high sensitive C-reactive protein ( hsCRP ), interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years
Dean et al., J Biol Chem 1999 : We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts