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CPOX — NFKB1

Text-mined interactions from Literome

Chen et al., J Biol Chem 1999 : The cyclooxygenase-2 (COX-2) inhibitors, NS-398 and indomethacin, attenuated LPS induced NO release, iNOS expression, and NF-kappaB DNA-protein complex formation
Plummer et al., Oncogene 1999 (Colonic Neoplasms) : Induction of COX2 by inflammatory cytokines or hypoxia induced oxidative stress can be mediated by nuclear factor kappa B (NF-kappaB)
Lee et al., J Biol Chem 2000 : Incubation of macrophages with PAO1 led to NF-kappaB dependent expression of inducible nitric-oxide synthase, COX-2 , and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function
Nakao et al., Mol Cell Biochem 2000 : Activation of NFkappaB is necessary for IL-1beta induced cyclooxygenase-2 (COX-2) expression in human gingival fibroblasts
Hao et al., J Clin Invest 2000 (Dehydration) : RMIC COX2 expression was also induced by driving NF-kappaB activation with a constitutively active IkappaB kinase alpha (IKKalpha)
López-Urrutia et al., Biochem Biophys Res Commun 2001 (Brucellosis...) : For this purpose, the induction of cyclooxygenase-2 (COX-2) , the production of the chemokine monocyte chemoattractant protein-1 ( MCP-1 ), and the activation of the nuclear factor kappa B (NF-kappa B) were studied
Nakao et al., Mol Cell Biochem 2002 : Tumor necrosis factor alpha (TNF-alpha) induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts
Tomita et al., Respirology 2002 : Using a human airway cell line ( LC-2/ad ), lipopolysaccharide (LPS) induced gene expression of hBD-2 was studied in the absence or the presence of ( i ) dexamethasone, ( ii ) inhibition of NF-kappaB and AP-1, ( iii ) intracellular calcium chelator, and ( iv ) cyclooxygenase (COX) inhibitors ... These findings suggest that glucocorticoids ( GC ), but not COX inhibitors, reduce hBD-2 gene expression, while NF-kappaB , AP-1 and intracellular calcium are essential for hBD-2 expression
Surh et al., Ann N Y Acad Sci 2002 : These ginsenosides also suppressed expression of cyclooxygenase-2 (COX-2) and activation of NF-kappaB in the TPA treated dorsal skin of mice
Chiang et al., J Pharm Pharmacol 2003 : We have investigated the role of protein kinase C ( PKC ) and nuclear factor-kappaB (NF-kappaB) in cyclooxygenase-2 (COX-2) expression caused by Staphylococcus aureus lipoteichoic acid in RAW 264.7 macrophages
Yoneda et al., J Med Microbiol 2003 : Following infection of HEp-2 cells with C. pneumoniae, NF-kappa B was activated, COX-2 was induced and PGE ( 2 ) was elevated
Murakami et al., Cancer Lett 2003 : Degradation of IkappaB ( IkappaB ) is a key step for nuclear factor-kappaB (NF-kappaB) induced transcription of certain proinflammatory genes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2
Jung et al., FASEB J 2003 (Inflammation...) : IL-1 mediated NFkB dependent cyclooxygenases-2 (COX-2) expression served as a positive effector for HIF-1alpha induction
Chen et al., Blood 2004 : Inhibition of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinase ( MAPK ) pathway signaling by CsA may be responsible for the CsA mediated effects on the regulation of chemokine receptor and cyclooxygenase-2 (COX-2) expression
Kiritoshi et al., Diabetes 2003 (Diabetes Mellitus, Experimental...) : Our results suggest that hyperglycemia increases mitochondrial ROS production, resulting in NF-kappaB activation, COX-2 mRNA induction , COX-2 protein production, and PGE2 synthesis
Rao et al., J Biol Chem 2004 : The increase in COX 2 following GSK 3beta inhibition was entirely blocked by NFkappaB inhibition using mutant IkappaB adenovirus
Beak et al., Biochimie 2004 : These results suggest that the NADPH oxidase and COX may be major sources for the UVB induced ROS generation, and play an essential role in the activation of NF-kappaB which is involved in the expression of a variety of genes induced by UVB in HaCaT cells
Benito et al., Ann Rheum Dis 2005 (Disease Progression...) : The inflammatory cell infiltrate, blood vessel formation, and angiogenic factors, NF-kappaB activation , expression of tumour necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta), and the presence of cyclo-oxygenase (COX)-1 and COX-2 were quantified
Ackerman et al., Biol Reprod 2005 : We and others have demonstrated an essential role for nuclear factor kappaB (NFkappaB) in cytokine-driven COX2 expression
Kim et al., J Pharm Pharmacol 2005 (Disease Models, Animal...) : Taken together, the data demonstrate that MEMO has anti-inflammatory and antinociceptive activity, inhibiting iNOS, COX-2 and TNF-alpha expression by down regulating NF-kappaB binding activity
Jung et al., Mech Ageing Dev 2006 (Inflammation) : NF-kappaB plays a key role in pro-inflammatory gene expression, such as cyclooxygenase (COX)
Collino et al., Eur J Pharmacol 2006 (Brain Ischemia...) : Pre-treatment with either rosiglitazone or pioglitazone significantly reduced oxidative stress, COX-2 protein expression and activation of MAPKs and NF-kappaB
Ivanov et al., Exp Cell Res 2006 (Melanoma) : We report here the use of a combination of sodium arsenite, an inhibitor of NF-kappaB activation, and NS398, a cyclooxygenase-2 (COX-2) inhibitor , for restoration of the surface FasL expression
Homhual et al., J Nat Prod 2006 : Bruguierin A ( 1 ) also inhibited phorbol ester induced NFkappaB ( nuclear factor-kappaB ) luciferase activation with an IC ( 50 ) value of 1.4 microM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC ( 50 ) value of 0.37 microM
Hardy et al., Mol Endocrinol 2006 (Inflammation) : In the present study, we tested the hypothesis that progesterone/PR inhibits uterine contractility by blocking nuclear factor kappaB (NF-kappaB) activation and induction of cyclooxygenase-2 (COX-2) , a contractile gene that is up-regulated in labor
Madrigal et al., CNS Neurol Disord Drug Targets 2006 (Atrophy) : NFkappaB activation results in the induction of iNOS and COX2 , two enzymes responsible for a great portion of the neurological damage produced in models of stress
Mathew et al., Am J Respir Cell Mol Biol 2007 : Macrophage activation was determined by measuring surface expression of CD11b, activation of NF-kappaB , phagocytic activity and production of reactive oxygen species, and cyclooxygenase (COX)-2 gene expression and production of prostaglandins
Lee et al., J Biomed Sci 2008 (Colitis...) : In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) , and inhibited the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue
Yokozawa et al., J Pharm Pharmacol 2007 (Disease Models, Animal...) : Furthermore, it inhibited the increase of cyclooxygenase (COX)-2 with the regulation of nuclear factorkappa B (NF-kappaB) and bcl-2 proteins in the liver, suggesting that the protective potential of Kangenkaryu extract against metabolic syndrome would be attributed to the regulation of COX-2, NF-kappaB, and bcl-2 signalling pathways
Travaglione et al., Infectious agents and cancer 2008 : CNF1 is receiving an increasing attention as a putative factor involved in transformation because of its ability to : ( i ) induce COX2 expression, an immediate-early gene over expressed in some type of cancers ; ( ii ) induce a long lasting activation of the transcription factor NF-kB , a largely accepted marker of tumor cells ; ( iii ) protect epithelial cells from apoptosis ; ( iv ) ensue the release of pro-inflammatory cytokines in epithelial and endothelial cells ; and ( v ) promote cellular motility
Ye et al., Am J Physiol Heart Circ Physiol 2008 (Disease Models, Animal...) : We investigated 1 ) whether 3-day ATV pretreatment limits IS in eNOS ( -/- ) and iNOS ( -/- ) mice and 2 ) whether COX2 expression and/or activation by ATV is eNOS, iNOS, and/or NF-kappaB dependent
Martins et al., Cell Physiol Biochem 2008 : In the present study, we investigated the effect of insulin on the LPS induced production of nitric oxide ( NO ) and prostaglandin ( PG ) -E ( 2 ), on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 , and on nuclear factor kappa B (NF-kappaB) activation in AMs
Lee et al., J Cell Biochem 2009 : H ( 2 ) O ( 2 ) increased NF-kappaB phosphorylation to induce an increase in the levels of cyclooxygenase (COX)-2 proteins
Cho et al., American journal of physiology. Renal physiology 2009 (Disease Models, Animal...) : The untreated CKD rats exhibited azotemia, hypertension, hypertriglyceridemia, proteinuria, glomerulosclerosis, tubulointerstitial damage, upregulation of MCP-1, plasminogen activator inhibitor-1 ( PAI-1 ), transforming growth factor ( TGF ) -beta, cyclooxygenase (COX)-1 , COX-2, and NAD ( P ) H oxidase ( NOX-4, gp91(phox), p47(phox) and p22(phox) subunits ) and activation of NF-kappaB ( IkappaB phosphorylation )
Min et al., J Ethnopharmacol 2009 (Inflammation) : Inflammatory makers, such as expression of pro-inflammatory cytokines and cyclooxygenase (COX)-2 , and activation of nuclear factor-kappa B (NF-kappaB) , were measured by enzyme linked immunosorbent assays and immunoblot analyses
Shimpo et al., J Orthop Sci 2009 (Osteoarthritis) : IL-1beta strongly increased the translocation of NF-kappaB to the nucleus and the phosphorylation of extracellular-signal regulated kinase, p38, and c-Jun amino-terminal kinase ; but the up-regulation was not inhibited by DEX or COX inhibitors
Shan et al., J Biomed Biotechnol 2009 (Brain Injuries...) : Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) , inhibited nuclear translocation of nuclear factor-kappaB (NF-kappaB) , increased the activity of copper/zinc superoxide dismutase ( Cu/Zn-SOD ) and catalase (CAT), and reduced the content of malondialdehyde ( MDA ), respectively
Moon et al., Int Immunopharmacol 2010 (Arthritis, Experimental...) : Additionally, by altering nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin inhibited PGE ( 2 ) production, COX-2 expression, and MMP secretion
Ivanov et al., Cell Signal 2010 : The NF-kappaB dependent gene expression of IL8, IL6, PTGS2/COX2 , TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 ( PGE2 ) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB dependent gene expression in bystander cells
Yasuda et al., Tohoku J Exp Med 2010 (Arthritis, Rheumatoid) : Anti-CD44 antibody reversed the inhibitory effects of HA on the LPS mediated increase in PGE ( 2 ) production, COX-2 induction, and activation of NF-kappaB
Wong et al., Circulation 1998 (Cardiomyopathy, Dilated...) : Induction of cyclooxygenase (COX) , the enzyme responsible for generating prostanoids, requires activation of nuclear factor-kappaB (NF-kappaB)