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CPT2 — TERF2IP

Text-mined interactions from Literome

Tiwari et al., Blood 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : The EPAC-specific cAMP analog 8CPT-2Me-cAMP ( 8- ( 4-chloro-phenylthio ) -2'-O-methyladenosine-3',5'-cAMP ) activates Rap1 in B-CLL cells, but, unlike rolipram/forskolin or 8-Bromo-cAMP, it does not induce PKA activation, as judged by phosphorylation of the transcription factor cAMP-response element binding protein ( CREB )
Cullen et al., Am J Physiol Gastrointest Liver Physiol 2004 : Glucagon, CPT-cAMP, and CPT-2-Me-cAMP all activated Rap 1 , a downstream effector of cAMP-GEF
Murphy et al., Blood 2005 (Anemia, Sickle Cell) : The cAMP dependent exchange factor Epac ( exchange protein directly activated by cAMP ) is a likely upstream activator of Rap1, since Epac is present in these cells and the Epac-specific cAMP analog 8CPT-2-Me ( 8- ( 4-cholorophenylthio ) -2'-O-methyl-cAMP ) activated Rap1 and promoted SS RBC adhesion to laminin ... Surprisingly, 8CPT-2-Me activated Rap1 did not promote SS RBC adhesion to a known alpha4beta1 ligand, vascular cell adhesion molecule 1 ( VCAM-1 )
Kim et al., J Biol Chem 2012 : Furthermore, 8CPT-2Me-cAMP increased the co-immunoprecipitation of profilin with Rap1 , whereas Tat-C3 toxin decreased that of profilin with RhoA