Gene interactions and pathways from curated databases and text-mining

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CRK — FOXO1

Text-mined interactions from Literome

Naïmi et al., Endocrinology 2007 (MAP Kinase Signaling System) : In contrast, Foxo1-ADA increases p38 activity, and p38 is required for effects of Foxo1 on PKB, at least in part
Taniguchi Ishikawa et al., Proc Natl Acad Sci U S A 2012 : Cell cycle quiescence is associated with down-regulation of cyclin D1, up-regulation of the cyclin dependent kinase inhibitors, p21 ( cip1. ) and p16(INK4a), and Forkhead transcriptional factor 1 ( Foxo1 ), and activation of p38 mitogen activated protein kinase ( MAPK ), indicating that H-Cx43-deficient HSCs are prone to senescence