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CSK — SHC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
CSK
—
SHC1
(physical association, affinity chromatography technology)
Brehme et al., Proc Natl Acad Sci U S A 2009
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IRef Biogrid Interaction:
CSK
—
SHC1
(direct interaction, pull down)
Sato et al., J Biol Chem 2002*
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IRef Hprd Interaction:
CSK
—
SHC1
(in vivo)
Farooq et al., J Biol Chem 1999*, Sato et al., J Biol Chem 2002*
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IRef Hprd Interaction:
CSK
—
SHC1
(in vitro)
Farooq et al., J Biol Chem 1999*, Sato et al., J Biol Chem 2002*
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IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
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IRef Intact Interaction:
Complex of 11 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Ophid Interaction:
CSK
—
SHC1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
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IRef Ophid Interaction:
CSK
—
SHC1
(aggregation, confirmational text mining)
Farooq et al., J Biol Chem 1999*
Text-mined interactions from Literome
Daulhac et al., J Biol Chem 1999
:
Expression of
Csk , which inactivates Src-family kinases, totally inhibited gastrin induced Src-like activity detected in anti-Src and anti-Shc precipitates but
diminished by 50 %
Shc phosphorylation and ERK-1 activation
Luttrell et al., J Biol Chem 1996
:
Coexpression of
Csk , which inactivates Src family kinases by phosphorylating the regulatory C-terminal tyrosine residue,
inhibited LPA stimulation of
Shc tyrosine phosphorylation, Shc.Grb2 complex formation, and MAP kinase activation