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CTNNB1 — NOTCH1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Balint et al., J Clin Invest 2005
(Disease Progression...) :
Furthermore, the oncogenic effect of
Notch1 on primary melanoma cells was
mediated by
beta-catenin , which was upregulated following Notch1 activation
Estrach et al., Development 2006
:
beta-catenin stimulates
Notch signalling by inducing Jag1 transcription
Lee et al., Am J Physiol Cell Physiol 2009
:
Hypoxia increased the level of Notch-1 and
Wnt-1/beta-catenin expression, which was blocked by the inhibition of COX-2, and inhibition of
Notch-1 by gamma-secretase inhibitor
blocked Wnt-1 activation
Kwon et al., Nat Cell Biol 2009
:
Here, we show that Wnt/beta-catenin signalling, which promotes expansion of CPCs, is negatively regulated by
Notch1 mediated control of phosphorylated
beta-catenin accumulation within CPCs, and that Notch1 activity in CPCs is required for their differentiation
Shi et al., J Biol Chem 2010
:
Inhibition of
Notch signaling, which has previously been shown to induce bHLH transcription factor expression,
increased beta-catenin expression in progenitor cells of the nervous system
Coant et al., Mol Cell Biol 2010
:
This conversion correlates with the following : ( i ) the redox dependent
activation of the dual phosphatase PTEN, causing the inactivation of the Wnt pathway effector
beta-catenin , and ( ii ) the downregulation of
Notch1 signaling that provokes derepression of mouse atonal homolog 1 ( Math1 ) expression
Corada et al., Dev Cell 2010
:
Both in vivo and in vitro data show that
beta-catenin upregulates Dll4 transcription and strongly
increases Notch signaling in the endothelium, leading to functional and morphological alterations