Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

CTNNB1 — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sharma et al., J Biol Chem 2002 (Prostatic Neoplasms) : Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation
Morrison et al., J Virol 2003 : The cytoplasmic accumulation of beta-catenin downstream of LMP2A was independent of PI3K signaling, whereas its nuclear translocation was dependent on PI3K signaling
Everly et al., J Virol 2004 : Activation of PI3K can affect the activity of beta-catenin , the target of the wnt signaling pathway ... Neither the cytoplasmic accumulation of beta-catenin nor the nuclear inactivation of GSK3beta was affected by the inhibition of PI3K signaling
Almeida et al., J Biol Chem 2005 : Wnt3a induced phosphorylation of GSK-3beta and downstream activation of beta-catenin mediated transcription required ERK, PI3K , and Akt signaling
Chung et al., J Endocrinol 2008 : Our data also suggest that PI3K/Akt mediated inactivation of GSK-3beta and stabilization of beta-catenin contribute to the anti-apoptotic effects of ghrelin
Xia et al., Mol Cell Biol 2010 : Interestingly, the activation of PI3K/Akt appeared to be independent of the activation of PKA, whereas both PI3K/Akt and PKA signaling inactivated GSK-3 and increased beta-catenin translocation
Sonderegger et al., Endocrinology 2010 : Chemical inhibition of PI3K abolished Wnt dependent phosphorylation of AKT and GSK-3beta and trophoblast motility but did not affect appearance of activated beta-catenin or Wnt/TCF reporter activity
Venkatesan et al., Cell Signal 2010 : Further, WISP1 stimulates PI3K-Akt dependent GSK3beta phosphorylation and beta-catenin nuclear translocation
Lee et al., Bone 2010 : Role of PI3K on the regulation of BMP2 induced beta-Catenin activation in human bone marrow stem cells ... In addition, BMP2 induced beta-Catenin activity and ALP activity were blocked by PI3K inhibition
Wang et al., J Bone Miner Res 2010 : T ( 3 ) -mediated Wnt-4 expression, beta-catenin activation, cell proliferation, and terminal differentiation of growth plate chondrocytes are partially prevented by the IGF1R inhibitor picropodophyllin as well as by the PI3K/Akt signaling inhibitors LY294002 and Akti1/2
Lee et al., Gastroenterology 2010 (Colitis...) : PI3K inhibition in interleukin-10 ( -/- ) mice impaired colitis induced epithelial Akt and beta-catenin activation, reduced progenitor cell expansion, and prevented dysplasia ... Biochemical analyses indicated that PI3K-Akt signaling increased nuclear total beta-catenin and P-beta-catenin ( 552 ) levels and reduced N-terminal beta-catenin phosphorylation, which is associated with degradation ... PI3K induced and Akt mediated beta-catenin signaling are required for progenitor cell activation during the progression from CUC to CAC ; these factors might be used as biomarkers of dysplastic transformation in the colon