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CTNNB1 — SKP1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → SCF complex (BTRC-SKP1-CUL1) (modification, collaborate)
  Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1) (modification, collaborate)
  Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TRRAP (TRRAP) → TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1) (modification, collaborate)
  Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: SCF complex (BTRC-SKP1-CUL1) → TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1) (modification, collaborate)
  Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
  Evidence: physical interaction
• NCI Pathway Database Degradation of beta catenin: SCF complex (BTRC-SKP1-CUL1) → APC/beta catenin complex (APC-CTNNB1) (modification, activates)
  Hart et al., Curr Biol 1999, Kitagawa et al., EMBO J 1999, Winer et al., J Biol Chem 2006, Seo et al., Cell Signal 2009, Su et al., Mol Cell 2008
  Evidence: assay, physical interaction
• Reactome Reaction: CTNNB1 → SKP1 (reaction) Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999
• Reactome Reaction: CTNNB1 → SKP1 (indirect_complex) Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — SKP1 (physical association, affinity chromatography technology) Wang et al., Cancer Sci 2011*
• IRef Biogrid Interaction: CTNNB1 — SKP1 (physical association, affinity chromatography technology) Matsuzawa et al., Mol Cell 2001
• IRef Biogrid Interaction: CTNNB1 — SKP1 (direct interaction, enzymatic study) Dimitrova et al., J Biol Chem 2010*
• IRef Biogrid Interaction: CTNNB1 — SKP1 (direct interaction, unspecified method) Winston et al., Genes Dev 1999
• IRef Hprd Interaction: Complex of BTRC-BTRC-SKP1-CTNNB1-SKP1-CTNNB1-BTRC-SKP1-CTNNB1 (in vivo) Wu et al., Mol Cell 2003
• IRef Intact Interaction: Complex of RBX1-BTRC-CUL1-UBE2D2-CTNNB1-UBA1-SKP1 (ubiquitination reaction, enzymatic study) Duda et al., Cell 2008
• IRef Intact Interaction: Complex of BTRC-CTNNB1-SKP1 (physical association, x-ray crystallography) Wu et al., Mol Cell 2003

Text-mined interactions from Literome

Angers et al., Nat Cell Biol 2006 : Considered with evidence that the distinct Cullin-1 based SCF(beta-TrCP)complex regulates beta-catenin stability, our data on the stability of Dishevelled demonstrates that two distinct ubiquitin ligase complexes regulate the Wnt-beta-catenin pathway
Megy et al., FEBS Lett 2006 (Neoplasms) : Phosphorylation of beta-Catenin at sites Ser33 and Ser37 on the DSGXXS motif is required for the interaction of beta-Catenin with the ubiquitin ligase SCF(beta-TrCP)