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CD4 — CTSS

Text-mined interactions from Literome

Kitamura et al., Immunity 2005 : Cathepsin S overexpression in DCs decreased intracellular MHCII alphabeta dimer, Ii, and H2-DM levels, LPS mediated surface expression of MHCII and suppressed CD4 ( + ) T cell activation ... Thus, IL-6-STAT3 mediated increase of cathepsin S activity reduces the MHCII alphabeta dimer, Ii, and H2-DM levels in DCs, and suppresses CD4 ( + ) T cell mediated immune responses
Costantino et al., J Immunol 2009 : CD4 ( + ) HLA-DR ( + ) T cells down-regulated cathepsin S expression and activity 18 h after activation, thereby ceasing nascent class II MHC product formation